Cancer is a complex disease characterized by loss of cellular homeostasis through genetic
and epigenetic alterations. Emerging evidence highlights a role for histone variants and their …

Histone variants represent chromatin components that diversify the structure and function of
the genome. The variants of H2A, primarily H2A. X, H2A. Z and macroH2A, are well …

MacroH2A has established tumour suppressive functions in melanoma and other cancers,
but an unappreciated role in the tumour microenvironment. Using an autochthonous …

Background Poly-ADP-ribose polymerases (PARPs) are key mediators of cellular stress
response. They are intimately linked to cellular metabolism through the consumption of …

Histone variants are chromatin components that replace replication-coupled histones in a
fraction of nucleosomes and confer particular characteristics to chromatin. H2A variants …

MacroH2A histone variants suppress tumor progression and act as epigenetic barriers to
induced pluripotency. How they impart their influence on chromatin plasticity is not well …

Investigations of the human germline and programming are challenging because of limited
access to embryonic material. However, the pig as a model may provide insights into …

While it is well known that expression levels of metabolic enzymes regulate the metabolic
state of the cell, there is mounting evidence that the converse is also true, that metabolite …

Epigenetic modifications are chemical modifications that affect gene expression without
altering DNA sequences. In particular, epigenetic chemical modifications can occur on …

Simple Summary The structural unit of chromatin is the nucleosome that is composed of
DNA wrapped around a core of eight histone proteins. Histone variants can replace …