Andrographolide, a natural anti-inflammatory agent: An Update

X Li, W Yuan, J Wu, J Zhen, Q Sun, M Yu - Frontiers in pharmacology, 2022 - frontiersin.org
Botanicals have attracted much attention in the field of anti-inflammatory due to their good
pharmacological activity and efficacy. Andrographis paniculata is a natural plant ingredient …

The role of peroxisome proliferator-activated receptors in the modulation of hyperinflammation induced by SARS-CoV-2 infection: A perspective for COVID-19 therapy

A Hasankhani, A Bahrami, B Tavakoli-Far… - Frontiers in …, 2023 - frontiersin.org
Coronavirus disease 2019 (COVID-19) is a severe respiratory disease caused by infection
with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that affects the lower …

Differential co-expression network analysis reveals key hub-high traffic genes as potential therapeutic targets for COVID-19 pandemic

A Hasankhani, A Bahrami, N Sheybani, B Aria… - Frontiers in …, 2021 - frontiersin.org
Background The recent emergence of COVID-19, rapid worldwide spread, and incomplete
knowledge of molecular mechanisms underlying SARS-CoV-2 infection have limited …

Andrographolide Induces anti-SARS-CoV-2 Response Through host-directed Mechanism: an in silico Study

BS Das, NC Das, SS Swain, S Mukherjee… - Future …, 2022 - Taylor & Francis
Aim: Considering the present alarming situation of COVID-19 pandemic, we concentrated on
evaluating the efficacy of a novel natural antiviral drug-candidate andrographolide against …

[HTML][HTML] Efficacy of Andrographis paniculata extract treatment in mild to moderate COVID-19 patients being treated with favipiravir: A double-blind, randomized …

T Siripongboonsitti, T Ungtrakul, K Tawinprai… - Phytomedicine, 2023 - Elsevier
Background While favipiravir had been the standard anti-SARS-CoV-3 drug for COVID-19
treatment in Thailand, the efficacy of favipiravir treatment is controversial. Andrographis …

Deciphering the potential anti-COVID-19 active ingredients in Andrographis paniculata (Burm. F.) Nees by combination of network pharmacology, molecular docking …

R Xie, Z Lin, C Zhong, S Li, B Chen, Y Wu, L Huang… - RSC …, 2021 - pubs.rsc.org
Currently, coronavirus disease 2019 (COVID-19) caused by Severe Acute Respiratory
Syndrome Coronavirus 2 has posed an enormous threat to public health worldwide. An …

Andrographolide: A herbal-chemosynthetic approach for enhancing immunity, combating viral infections, and its implication on human health

A Mishra, HA Shaik, RK Sinha, BR Shah - Molecules, 2021 - mdpi.com
Plants consistently synthesize and accumulate medically valuable secondary metabolites
which can be isolated and clinically tested under in vitro conditions. An advancement with …

Investigating a library of flavonoids as potential inhibitors of a cancer therapeutic target MEK2 using in silico methods

WM AlZahrani, SA AlGhamdi, SS Sohrab… - International Journal of …, 2023 - mdpi.com
The second leading cause of death in the world is cancer. Mitogen-activated protein kinase
(MAPK) and extracellular signal-regulated protein kinase (ERK) 1 and 2 (MEK1/2) stand out …

Andrographolide, diterpenoid constituent of Andrographis paniculata: Review on botany, phytochemistry, molecular docking analysis, and pharmacology

DP Gonde, BK Bhole, KS Kakad - Annales Pharmaceutiques Françaises, 2024 - Elsevier
Andrographis paniculata (kalmegh) is also known as “king of bitters”, is an herbaceous plant
belongs to family Acanthaceae. The therapeutic effect is due to presence of diterpenoid …

Investigation on the mechanism of 2, 3, 4′, 5-Tetrahydroxystilbene 2-oD-glucoside in the treatment of inflammation based on network pharmacology

L Sun, B Wang, T Sun, F Zhou, B Zhu, C Li… - Computers in biology …, 2022 - Elsevier
Background Inflammation is the pathogenesis of various chronic diseases plaguing clinic for
years. Fallopia multiflora (Thunb.) is a traditional Chinese herbal medicine with a long …