Restoring lost nigrostriatal fibers in Parkinson's disease based on clinically-inspired design criteria

WJ Gordián-Vélez, D Chouhan, RA España… - Brain research …, 2021 - Elsevier
Parkinson's disease is a neurodegenerative disease affecting around 10 million people
worldwide. The death of dopaminergic neurons in the substantia nigra and the axonal fibers …

Non-human primate models of focal cortical ischemia for neuronal replacement therapy

J Mu, P Hao, H Duan, W Zhao… - Journal of Cerebral …, 2023 - journals.sagepub.com
Despite the high prevalence, stroke remains incurable due to the limited regeneration
capacity in the central nervous system. Neuronal replacement strategies are highly diverse …

Intracerebral administration of a novel self-assembling peptide hydrogel is safe and supports cell proliferation in experimental intracerebral haemorrhage

F Bolan, BR Dickie, JR Cook, JM Thomas… - Translational stroke …, 2024 - Springer
Intracerebral haemorrhage (ICH) is the deadliest form of stroke, but current treatment options
are limited, meaning ICH survivors are often left with life-changing disabilities. The …

[HTML][HTML] bFGF-Chitosan “brain glue” promotes functional recovery after cortical ischemic stroke

J Mu, X Zou, X Bao, Z Yang, P Hao, H Duan, W Zhao… - Bioactive Materials, 2025 - Elsevier
The mammalian brain has an extremely limited ability to regenerate lost neurons and to
recover function following ischemic stroke. A biomaterial strategy of slowly-releasing various …

In vitro model of traumatic brain injury to screen neuro-regenerative biomaterials

RH Basit, N Tzerakis, SI Jenkins, DM Chari - Materials Science and …, 2021 - Elsevier
Penetrating traumatic brain injury (pTBI) causes serious neurological deficits with no clinical
regenerative therapies currently available. Tissue engineering strategies using biomaterial …

[HTML][HTML] Neurorestorative approaches for ischemic stroke

P Michór, L Renardson, S Li, J Boltze - Neuroscience, 2024 - Elsevier
Despite recent advances in acute stroke management, most patients experiencing a stroke
will suffer from residual brain damage and functional impairment. Addressing those residual …

An implantable human stem cell-derived tissue-engineered rostral migratory stream for directed neuronal replacement

JC O'Donnell, EM Purvis, KVT Helm… - Communications …, 2021 - nature.com
The rostral migratory stream (RMS) facilitates neuroblast migration from the subventricular
zone to the olfactory bulb throughout adulthood. Brain lesions attract neuroblast migration …

A three-dimensional tissue-engineered rostral migratory stream as an in vitro platform for subventricular zone-derived cell migration

EM Purvis, AD Garcia-Epelboim, EN Krizman… - … in Bioengineering and …, 2024 - frontiersin.org
In the brains of most adult mammals, neural precursor cells (NPCs) from the subventricular
zone (SVZ) migrate through the rostral migratory stream (RMS) to replace olfactory bulb …

Electrical Stimulation for Stem Cell-Based Neural Repair: Zapping the Field to Action

SN Iwasa, X Liu, HE Naguib, SK Kalia, MR Popovic… - Eneuro, 2024 - eneuro.org
Neurological disorders are a leading cause of death and disabilities worldwide and
represent an enormous public health challenge (Feigin and Vos, 2019). A conservative …

Challenges, Opportunities, and Recent Advances

P Michór, L Renardson, S Li, J Boltze - Neuroscience, 2024 - ibroneuroscience.org
Despite recent advances in acute stroke management, most patients experiencing a stroke
will suffer from residual brain damage and functional impairment. Addressing those residual …