[HTML][HTML] Blaming the brain for obesity: integration of hedonic and homeostatic mechanisms

HR Berthoud, H Münzberg, CD Morrison - Gastroenterology, 2017 - Elsevier
The brain plays a key role in the controls of energy intake and expenditure, and many genes
associated with obesity are expressed in the central nervous system. Technological and …

Browning of white fat: novel insight into factors, mechanisms, and therapeutics

N Jeremic, P Chaturvedi… - Journal of cellular …, 2017 - Wiley Online Library
What is more interesting about brown adipose tissue (BAT) is its ability to provide
thermogenesis, protection against obesity by clearing triglycerides, releasing batokines, and …

A review of decellurization methods caused by an urgent need for quality control of cell‐free extracellular matrix'scaffolds and their role in regenerative medicine

M Kawecki, W Łabuś, A Klama‐Baryla… - … Research Part B …, 2018 - Wiley Online Library
The natural extracellular matrix (ECM), thanks to its specific properties (eg, collagenous
lattice, a reservoir of growth factors, ECM‐cell anchoring areas, an optimal pH and CO2) …

Actomyosin-mediated tension orchestrates uncoupled respiration in adipose tissues

KM Tharp, MS Kang, GA Timblin, J Dempersmier… - Cell metabolism, 2018 - cell.com
The activation of brown/beige adipose tissue (BAT) metabolism and the induction of
uncoupling protein 1 (UCP1) expression are essential for BAT-based strategies to improve …

Aging impairs beige adipocyte differentiation of mesenchymal stem cells via the reduced expression of Sirtuin 1

VC Khanh, AF Zulkifli, C Tokunaga, T Yamashita… - Biochemical and …, 2018 - Elsevier
In the body, different types of adipose tissue perform different functions, with brown and
beige adipose tissues playing unique roles in dissipating energy. Throughout life …

Controllable fabrication of alginate/poly-L-ornithine polyelectrolyte complex hydrogel networks as therapeutic drug and cell carriers

W Xue, B Liu, H Zhang, S Ryu, M Kuss, D Shukla, G Hu… - Acta Biomaterialia, 2022 - Elsevier
Polyelectrolyte complex (PEC) hydrogels are advantageous as therapeutic agent and cell
carriers. However, due to the weak nature of physical crosslinking, PEC swelling and cargo …

Integrins and extracellular matrix proteins modulate adipocyte thermogenic capacity

MA Gonzalez Porras, K Stojkova, MK Vaicik… - Scientific reports, 2021 - nature.com
Obesity and the metabolic disease epidemic has led to an increase in morbidity and
mortality. A rise in adipose thermogenic capacity via activation of brown or beige fat is a …

Fat-on-a-chip models for research and discovery in obesity and its metabolic comorbidities

M McCarthy, T Brown, A Alarcon… - … Engineering Part B …, 2020 - liebertpub.com
The obesity epidemic and its associated comorbidities present a looming challenge to
health care delivery throughout the world. Obesity is characterized as a sterile inflammatory …

[HTML][HTML] Hyaluronan in adipogenesis, adipose tissue physiology and systemic metabolism

Y Zhu, IL Kruglikov, Y Akgul, PE Scherer - Matrix Biology, 2019 - Elsevier
Hyaluronic acid (HA, also known as hyaluronan), is a non-sulfated linear glycosaminoglycan
polymer consisting of repeating disaccharide units of d-glucuronic acid and N-acetyl-d …

Adipose tissue and the physiologic underpinnings of metabolic disease

RW O'Rourke - Surgery for Obesity and Related Diseases, 2018 - Elsevier
Adipose tissue dysfunction underlies the pathogenesis of metabolic disease. The metrics
used to quantify adiposity and its association with metabolic disease, including body mass …