Simple Summary In this review, we describe the basic functions of endothelin and related
molecules, including their receptors and enzymes. Furthermore, we discuss the important …

Abstract When endothelin-1 (ET-1) was discovered it was hailed as the prototypical
endothelium-derived contracting factor (EDCF). However, over the years little evidence …

Background Premenopausal women are less likely to develop hypertension and salt‐related
complications than are men, yet the impact of sex on mechanisms regulating Na+ …

Background The novel estrogen receptor, G‐protein–coupled estrogen receptor (GPER), is
responsible for rapid estrogen signaling. GPER activation elicits cardiovascular and …

The endothelin (ET) system seems to play a pivotal role in hypertension and in proteinuric
kidney disease, including the micro-and macro-vascular complications of diabetes …

Cardiovascular (CV) and renal diseases are increasingly prevalent in the United States and
globally. CV-related mortality is the leading cause of death in the United States, while renal …

Hypertension is a major risk factor for cardiovascular disease. In a significant minority of
people, it develops when salt intake is increased (salt-sensitivity). It is not clear whether this …

Endothelin (ET)‐1, which was originally found to be secreted by the vascular endothelium, is
highly expressed in the kidney, particularly in the renal medulla. 2. Recent studies using …

Endothelin receptor blockade is associated with a significant attenuation of proteinuria and
these effects are mediated in part via inhibition of inflammatory and oxidative stress related …