Clinical studies in a range of cancers have detected elevated levels of the Wnt antagonist
Dickkopf-1 (DKK1) in the serum or tumors of patients, and this was frequently associated …

Wnt signalling is a fundamental pathway involved in embryonic development and adult
tissue homeostasis. Mutations in the pathway frequently lead to developmental defects and …

Bone loss and increased fractures are common complications in chronic kidney disease.
Because Wnt pathway activation is essential for normal bone mineralization, we assessed …

Colorectal cancer (CRC) is one of the most life‐threatening neoplasias in terms of incidence
and mortality worldwide. Vitamin D deficiency has been associated with an increased risk of …

Colorectal cancer (CRC) is one of the most prevalent cancers and has a high mortality rate.
Insensitivity and the limited therapeutic efficacy of its standard chemotherapeutic drug, 5 …

Simple Summary Colorectal cancer (CRC) causes a high number (more than 800,000) of
deaths worldwide each year. Better methods for early diagnosis and the development of …

Abstract Dickkopf-1 (DKK-1) is a well-established inhibitor of canonical Wnt-signaling that
critically participates in the regulation of bone formation and has been implicated in the …

The Wnt signaling pathway regulates crucial aspects such as cell fate determination, cell
polarity and organogenesis during embryonic development. Wnt pathway deregulation is a …

Colorectal cancer (CRC) is the third most frequent malignancy and represents the fourth
most common cause of cancer‑associated mortalities in the world. Despite many advances …

Periostin (POSTN) expression in cancer cells and circulation has been related to poor
prognosis of colorectal carcinoma (CRC). However, the role of POSTN expressed in intra …