Self-healing injectable hydrogels for tissue regeneration

P Bertsch, M Diba, DJ Mooney… - Chemical …, 2022 - ACS Publications
Biomaterials with the ability to self-heal and recover their structural integrity offer many
advantages for applications in biomedicine. The past decade has witnessed the rapid …

Neuroinflammatory mechanisms of blood-brain barrier damage in ischemic stroke

C Yang, KE Hawkins, S Doré… - American Journal of …, 2019 - journals.physiology.org
As part of the neurovascular unit, the blood-brain barrier (BBB) is a unique, dynamic
regulatory boundary that limits and regulates the exchange of molecules, ions, and cells …

Regenerative therapies for central nervous system diseases: a biomaterials approach

RY Tam, T Fuehrmann, N Mitrousis… - …, 2014 - nature.com
The central nervous system (CNS) has a limited capacity to spontaneously regenerate
following traumatic injury or disease, requiring innovative strategies to promote tissue and …

Design of injectable materials to improve stem cell transplantation

LM Marquardt, SC Heilshorn - Current stem cell reports, 2016 - Springer
Stem cell-based therapies are steadily gaining traction for regenerative medicine
approaches to treating disease and injury throughout the body. While a significant body of …

Optimization of thermoresponsive chitosan/β-glycerophosphate hydrogels for injectable neural tissue engineering application

MH Bhuiyan, AN Clarkson, MA Ali - Colloids and Surfaces B: Biointerfaces, 2023 - Elsevier
Regeneration of neural tissue and recovery of lost functions following an accident or disease
to the central nervous system remains a major challenge worldwide, with limited treatment …

Concentration-dependent rheological properties of ECM hydrogel for intracerebral delivery to a stroke cavity

AR Massensini, H Ghuman, LT Saldin, CJ Medberry… - Acta biomaterialia, 2015 - Elsevier
Biomaterials composed of mammalian extracellular matrix (ECM) promote constructive
tissue remodeling with minimal scar tissue formation in many anatomical sites. However, the …

Defining and designing polymers and hydrogels for neural tissue engineering

ER Aurand, KJ Lampe, KB Bjugstad - Neuroscience research, 2012 - Elsevier
The use of biomaterials, such as hydrogels, as neural cell delivery devices is becoming
more common in areas of research such as stroke, traumatic brain injury, and spinal cord …

[HTML][HTML] Hydrogel-assisted neuroregeneration approaches towards brain injury therapy: A state-of-the-art review

VA Kornev, EA Grebenik, AB Solovieva… - Computational and …, 2018 - Elsevier
Recent years have witnessed the development of an enormous variety of hydrogel-based
systems for neuroregeneration. Formed from hydrophilic polymers and comprised of up to …

Non-invasive imaging of transplanted human neural stem cells and ECM scaffold remodeling in the stroke-damaged rat brain by 19F-and diffusion-MRI

E Bible, F Dell'Acqua, B Solanky, A Balducci… - Biomaterials, 2012 - Elsevier
Transplantation of human neural stem cells (hNSCs) is emerging as a viable treatment for
stroke related brain injury. However, intraparenchymal grafts do not regenerate lost tissue …

Stem cells as an emerging paradigm in stroke 4: advancing and accelerating preclinical research

J Boltze, MM Modo, RW Mays, A Taguchi, J Jolkkonen… - Stroke, 2019 - Am Heart Assoc
3300 Stroke November 2019 allow more realistic and precise testing of cell delivery
techniques including stereotaxic and intra-arterial cell administration and dose translation to …