Pathogenesis of human cytomegalovirus in the immunocompromised host

P Griffiths, M Reeves - Nature Reviews Microbiology, 2021 - nature.com
Human cytomegalovirus (HCMV) is a herpesvirus that infects~ 60% of adults in developed
countries and more than 90% in developing countries. Usually, it is controlled by a vigorous …

Global aspects of viral glycosylation

I Bagdonaite, HH Wandall - Glycobiology, 2018 - academic.oup.com
Enveloped viruses encompass some of the most common human pathogens causing
infections of different severity, ranging from no or very few symptoms to lethal disease as …

Quantitative temporal viromics: an approach to investigate host-pathogen interaction

MP Weekes, P Tomasec, EL Huttlin, CA Fielding… - Cell, 2014 - cell.com
A systematic quantitative analysis of temporal changes in host and viral proteins throughout
the course of a productive infection could provide dynamic insights into virus-host …

Pathogen at the gates: human cytomegalovirus entry and cell tropism

CC Nguyen, JP Kamil - Viruses, 2018 - mdpi.com
The past few years have brought substantial progress toward understanding how human
cytomegalovirus (HCMV) enters the remarkably wide spectrum of cell types and tissues that …

Cytomegalovirus: pathogen, paradigm, and puzzle

M Boeckh, AP Geballe - The Journal of clinical investigation, 2011 - Am Soc Clin Investig
Human cytomegalovirus (CMV), one of the eight herpesviruses that commonly infect
humans, is best known for its propensity to cause disease in immunocompromised patients …

Human cytomegalovirus gH/gL/gO promotes the fusion step of entry into all cell types, whereas gH/gL/UL128-131 broadens virus tropism through a distinct …

M Zhou, JM Lanchy, BJ Ryckman - Journal of virology, 2015 - Am Soc Microbiol
Interaction between gH/gL and the fusion protein gB is likely a conserved feature of the entry
mechanism for all herpesviruses. Human cytomegalovirus (HCMV) gH/gL can be bound by …

Modulation of innate and adaptive immunity by cytomegaloviruses

R Berry, GM Watson, S Jonjic… - Nature reviews …, 2020 - nature.com
The coordinated activities of innate and adaptive immunity are critical for effective protection
against viruses. To counter this, some viruses have evolved sophisticated strategies to …

High-resolution human cytomegalovirus transcriptome

D Gatherer, S Seirafian… - Proceedings of the …, 2011 - National Acad Sciences
Deep sequencing was used to bring high resolution to the human cytomegalovirus (HCMV)
transcriptome at the stage when infectious virion production is under way, and major …

Human cytomegalovirus: taking the strain

GWG Wilkinson, AJ Davison, P Tomasec… - Medical microbiology …, 2015 - Springer
In celebrating the 60th anniversary of the first isolation of human cytomegalovirus (HCMV),
we reflect on the merits and limitations of the viral strains currently being used to develop …

High-throughput analysis of human cytomegalovirus genome diversity highlights the widespread occurrence of gene-disrupting mutations and pervasive …

S Sijmons, K Thys, M Mbong Ngwese… - Journal of …, 2015 - Am Soc Microbiol
Human cytomegalovirus is a widespread pathogen of major medical importance. It causes
significant morbidity and mortality in immunocompromised individuals, and congenital …