Abstract Cys2-His2 (C2H2) zinc finger domains (ZFs) were originally identified as DNA-
binding domains, and uncharacterized domains are typically assumed to function in DNA …

The promyelocytic leukemia zinc finger (PLZF) protein, also known as Zbtb16 or Zfp145, was
first identified in a patient with acute promyelocytic leukemia, where a reciprocal …

Vitamin D 3 upregulated protein 1 (VDUP1) is a 1, 25-dihydroxyvitamin D 3 (1, 25 (OH) 2 D
3) upregulated protein, and it is induced by various stresses. In human tumor tissues …

The eukaryotic translation initiation factor 4E (eIF4E) acts as both a key translation factor and
as a promoter of nucleocytoplasmic transport of specific transcripts. Traditionally, its …

In recent years, the highly conserved promyelocytic leukemia zinc finger (PLZF, also known
as ZBTB16, ZNF145) has attracted attention as a multifunctional transcription factor involved …

Nuclear hormone receptors (NRs) are evolutionarily conserved ligand-dependent
transcription factors. They are essential for human life, mediating the actions of lipophilic …

The transcriptional repressor PLZF was identified by its translocation with retinoic acid
receptor alpha in t (11; 17) acute promyelocytic leukemia (APL). Ectopic expression of PLZF …

A major question in hematopoiesis is how the system maintains long-term homeostasis
whereby the generation of large numbers of differentiated cells is balanced with the …

Although phospholipid scramblase 1 (PLSCR1) was originally identified based on its
capacity to promote transbilayer movement of membrane phospholipids, subsequent studies …

1α, 25-dihydroxyvitamin D3 (1, 25D) is a powerful differentiation agent, which has potential
for treatment of acute myeloid leukemia (AML), but induces severe hypercalcemia at …