Background Cisplatin (cis-diamminedichloroplatinum II, CDDP) is one of the most effective
chemotherapeutic agents. However, its clinical use is limited due to the severe side effects …

For> 50 years, it has been recognized that immunity contributes to hypertension. Recent
data have defined an important role of T cells and various T cell–derived cytokines in …

Research studying the role of inflammation in hypertension and cardiovascular disease has
flourished in recent years; however, the exact mechanisms by which the activated immune …

Inflammasomes are components of the innate immune response that have recently emerged
as crucial controllers of tissue homeostasis. In particular, the nucleotide-binding domain …

Background Inhibition of sodium-glucose cotransporter-2 (SGLT2) has received remarkable
attention due to the beneficial effects observed in diabetes mellitus, heart failure, and kidney …

Hypertension is a major global health challenge, as it represents the main risk factor for
stroke and cardiovascular disease. It is a multifactorial clinical condition characterized by …

Frailty is a functional term that describes a decline in physiological functions that leads to
dependency, vulnerability to stressors, high risk for adverse health outcomes, increased risk …

Immune system activation contributes to the pathogenesis of hypertension and the resulting
progression of chronic kidney disease. In this regard, we recently identified a role for …

An essential link between the kidney and blood pressure control has long been known.
Here, we review evidence supporting the premise that an impaired capacity of the kidney to …

Hypertension is among the most prevalent and catastrophic chronic diseases worldwide.
While the efficacy of renin angiotensin system (RAS) blockade in lowering blood pressure …