Gene maps, or annotations, enable us to navigate the functional landscape of our genome.
They are a resource upon which virtually all studies depend, from single-gene to genome …

The application of a new generation of sequencing techniques has revealed that most of the
genome has already been transcribed. However, only a small part of the genome codes …

A number of technologies, including CRISPR/Cas, transcription activator-like effector
nucleases and zinc-finger nucleases, allow the user to target a chosen locus for genome …

Although a considerable portion of eukaryotic genomes is transcribed as long noncoding
RNAs (lncRNAs), the vast majority are functionally uncharacterised. The rapidly expanding …

Long noncoding RNAs (lncRNAs) are transcripts measuring> 200 bp in length and devoid of
protein-coding potential. LncRNAs exceed the number of protein-coding mRNAs and …

A DNA triplex has the advantages of improved nanostructure stability and pH environment
responsiveness compared with single-stranded and double-stranded nucleic acids …

The genomes of mammalian species are pervasively transcribed producing as many
noncoding as protein-coding RNAs. There is a growing body of evidence supporting their …

Abstract Background Long non-coding RNAs (lncRNAs) can exert functions via forming
triplex with DNA. The current methods in predicting the triplex formation mainly rely on …

The technology of triplex-forming oligonucleotides (TFOs) provides an approach to
manipulate genes at the DNA level. TFOs bind to specific sites on genomic DNA, creating a …

Long noncoding RNAs (lncRNAs), defined as nontranslated transcripts greater than 200
nucleotides in length, are often differentially expressed throughout developmental stages …