The renin-angiotensin-aldosterone system (RAAS) signaling pathways and cancer: foes versus allies

B Hassani, Z Attar, N Firouzabadi - Cancer Cell International, 2023 - Springer
The renin-angiotensin-aldosterone system (RAAS), is an old system with new fundamental
roles in cancer biology which influences cell growth, migration, death, and metastasis. RAAS …

Breaking the bottleneck in anticancer drug development: Efficient Utilization of Synthetic Biology

H Wang, Y He, M Jian, X Fu, Y Cheng, Y He, J Fang… - Molecules, 2022 - mdpi.com
Natural products have multifarious bioactivities against bacteria, fungi, viruses, cancers and
other diseases due to their diverse structures. Nearly 65% of anticancer drugs are natural …

Potential prognostic biomarkers of OSBPL family genes in patients with pancreatic ductal adenocarcinoma

CW Chou, YH Hsieh, SC Ku, WJ Shen, G Anuraga… - Biomedicines, 2021 - mdpi.com
Pancreatic ductal adenocarcinoma (PDAC) is a highly fatal malignancy with poor survival
outcomes. In addition, oxysterol-binding protein-like (OSBPL) family members are reported …

Antihypertensive drugs and cancer risk

S Kidoguchi, N Sugano, T Yokoo… - American Journal of …, 2022 - academic.oup.com
Hypertension is the most prevalent comorbidity in cancer patients. Consequently, many
cancer patients are prescribed antihypertensive drugs before cancer diagnosis or during …

Drug repurposing, an attractive strategy in pancreatic cancer treatment: preclinical and clinical updates

L De Lellis, S Veschi, N Tinari, Z Mokini, S Carradori… - Cancers, 2021 - mdpi.com
Simple Summary The purpose of this review is to provide an update on some of the most
promising non-oncology drugs that are already approved and that could be useful also in …

Concentrations of Transition Metal Ions in Rat Lungs after Tobacco Smoke Exposure and Treatment with His-Leu Dipeptide

M Szukalska, T Frączyk, E Florek, L Pączek - Molecules, 2023 - mdpi.com
Tobacco smoking is deleterious to the lungs because it exposes them to many toxic
substances. These include transition metal ions, such as cadmium. However, there is a lack …

Synergistic effects of calcium channel blockers and renin-angiotensin inhibitors with gemcitabine-based chemotherapy on the survival of patients with pancreatic …

L Kraj, P Chmiel, A Śliwczyński, Ł Szymański… - Journal of Cancer …, 2024 - Springer
Purpose Pancreatic cancer remains a significant public health challenge, with poor long-
term outcomes due to the lack of effective treatment options. Repurposing commonly used …

[HTML][HTML] Screening of Differentially Expressed Genes Based on the ACRG Molecular Subtypes of Gastric Cancer and the Significance and Mechanism of AGTR1 …

H Zhang, S Zhen, P Ding, B Tan, H Wang… - Journal of Personalized …, 2023 - mdpi.com
Background: The Asian Cancer Research Group (ACRG) classification is a molecular
classification established based on the tissues of gastric cancer (GC) patients in Asia …

The concomitant use of the renin–angiotensin system inhibitors and survival outcomes of patients with pancreatic adenocarcinoma: an analysis from a tertiary center

KY Tseng, CY Hsu, YH Shih, HC Lin… - Therapeutic …, 2024 - journals.sagepub.com
Background: The limited efficacy of chemotherapy in improving survival in pancreatic ductal
adenocarcinoma (PDAC) necessitates the exploration of novel strategies to overcome …

The Counteracting Effects of Ang II and Ang-(1-7) on the Function and Growth of Insulin-secreting NIT-1 Cells

X Lin, X Wang, W Feng, Y Wan, J Chai… - Current Diabetes …, 2024 - ingentaconnect.com
Introduction: China now has the highest number of diabetes in the world. Angiotensin II (Ang
II) causes insulin resistance by acting on the insulin signaling pathway of peripheral target …