Head and neck squamous cell carcinomas (HNSCCs) arise in the mucosal linings of the
upper aerodigestive tract and are unexpectedly heterogeneous in nature. Classical risk …

Retinoic acid (RA), the major bioactive metabolite of retinol or vitamin A, induces a spectrum
of pleiotropic effects in cell growth and differentiation that are relevant for embryonic …

MicroRNAs (miRNAs) are ubiquitous regulators of eukaryotic gene expression. In addition to
repressing translation, miRNAs can down-regulate the concentration of mRNAs that contain …

First described 15 years ago as a cysteine-rich sequence that was common to a small group
of homeodomain transcription factors, the LIM domain is now recognized as a tandem zinc …

Molecular scaffold or adaptor proteins facilitate precise spatiotemporal regulation and
integration of multiple signaling pathways to effect the optimal cellular response to changes …

Connections between the cytoskeleton and intercellular junctions profoundly influence cell
shape and motility. It is becoming increasingly clear that in addition to structural functions …

Amino acid availability regulates cellular physiology by modulating gene expression and
signal transduction pathways. However, although the signalling intermediates between …

Abstract α-catenin has often been considered to be a non-regulatory intercellular adhesion
protein, in contrast to β-catenin, which has well-documented dual roles in cell–cell adhesion …

Abstract The Hippo/Yap pathway is a well-conserved signaling cascade that regulates cell
proliferation and differentiation to control organ size and stem/progenitor cell behavior …

Small cell lung cancer (SCLC) is a subtype of lung cancer with poor prognosis. Expression
array analysis of 23 SCLC cases and 42 normal tissues revealed that EZH2 and other PRC2 …