Hemophagocytic lymphohistiocytosis (HLH) is a syndrome describing patients with severe
systemic hyperinflammation. Characteristic features include unremitting fever, cytopenias …

Hemophagocytic lymphohistiocytosis (HLH) is a syndrome of pathologic immune activation,
often associated with genetic defects of lymphocyte cytotoxicity. Though a distinctive …

Importance Neurological manifestations have been reported in adults with coronavirus
disease 2019 (COVID-19), which is caused by the highly pathogenic virus severe acute …

Objective Haemophagocytic lymphohistiocytosis (HLH) and macrophage activation
syndrome (MAS) are life-threatening systemic hyperinflammatory syndromes that can …

The historic term 'histiocytosis' meaning 'tissue cell'is used as a unifying concept for
diseases characterized by pathogenic myeloid cells that share histological features with …

Imaging plays a crucial role in differentiating the spectrum of paediatric acquired
demyelinating syndromes (ADS), which apart from myelin oligodendrocyte glycoprotein …

Isolated neuroinflammatory disease has been described in case reports of familial
hemophagocytic lymphohistiocytosis (FHL), but the clinical spectrum of disease …

Haemophagocytic lymphohistiocytosis (HLH) is a hyperinflammatory syndrome
characterised by persistently activated cytotoxic lymphocytes and macrophages, which, if …

The advent of high-throughput sequencing has facilitated genotype-phenotype correlations
in congenital diseases. This has provided molecular diagnosis and benefited patient …

Hemophagocytic lymphohistiocytosis (HLH) is a rare, life-threatening condition
characterized by hyperinflammation in an uncontrolled and ineffective immune response …