Various human malignancies are characterized by excessive activation of the Janus family
of cytoplasmic tyrosine kinases (JAK) and their associated transcription factors STAT3 and …

The transcription factors STAT5A and STAT5B have essential roles in survival and
proliferation of hematopoietic cells—which have been considered largely redundant …

Stat5 is constitutively activated in many human cancers affecting the expression of cell
proliferation and cell survival controlling genes. These oncogenic functions of Stat5 have …

Existing studies reported that some circular RNAs (circRNAs) play vital roles in the
development of pulmonary fibrosis. However, few studies explored the biomarker potential …

Liver fibrosis, or cirrhosis, is a common end-stage condition of many chronic liver diseases
after incomplete recovery from hepatocyte damage. During fibrosis progression …

Insulin‐like growth factors (IGFs) play an essential role in growth and development, as well
as in the overall cellular regulation and metabolism in the human body. In chronic liver …

Growth hormone (GH)‐activated signal transducer and activator of transcription 5 (STAT5)
and the glucocorticoid (GC)‐responsive glucocorticoid receptor (GR) are important signal …

The liver is a primary target of growth hormone (GH). GH signals are mediated by the
transcription factor signal transducer and activator of transcription 5 (STAT5). Here, we focus …

The rising prevalence of obesity came along with an increase in associated metabolic
disorders in Western countries. Non-alcoholic fatty liver disease (NAFLD) represents the …

Liver cirrhosis involves chronic wound healing and fibrotic processes. Mesenchymal stromal
cells (MSCs) are multipotent adult progenitor cells that are used as vehicles of therapeutic …