Personalized therapy for mycophenolate: consensus report by the international association of therapeutic drug monitoring and clinical toxicology
S Bergan, M Brunet, DA Hesselink… - Therapeutic drug …, 2021 - journals.lww.com
When mycophenolic acid (MPA) was originally marketed for immunosuppressive therapy,
fixed doses were recommended by the manufacturer. Awareness of the potential for a more …
fixed doses were recommended by the manufacturer. Awareness of the potential for a more …
Applications, challenges, and outlook for PBPK modeling and simulation: a regulatory, industrial and academic perspective
W Lin, Y Chen, JD Unadkat, X Zhang, D Wu… - Pharmaceutical …, 2022 - Springer
Several regulatory guidances on the use of physiologically based pharmacokinetic (PBPK)
analyses and physiologically based biopharmaceutics model (s)(PBBM (s)) have been …
analyses and physiologically based biopharmaceutics model (s)(PBBM (s)) have been …
[HTML][HTML] Physiologically-based pharmacokinetic models for children: Starting to reach maturation?
LFM Verscheijden, JB Koenderink, TN Johnson… - Pharmacology & …, 2020 - Elsevier
Developmental changes in children can affect the disposition and clinical effects of a drug,
indicating that scaling an adult dose simply down per linear weight can potentially lead to …
indicating that scaling an adult dose simply down per linear weight can potentially lead to …
[HTML][HTML] Recent advances in the translation of drug metabolism and pharmacokinetics science for drug discovery and development
Y Lai, X Chu, L Di, W Gao, Y Guo, X Liu, C Lu… - … Pharmaceutica Sinica B, 2022 - Elsevier
Drug metabolism and pharmacokinetics (DMPK) is an important branch of pharmaceutical
sciences. The nature of ADME (absorption, distribution, metabolism, excretion) and PK …
sciences. The nature of ADME (absorption, distribution, metabolism, excretion) and PK …
Understanding the chemical exposome during fetal development and early childhood: a review
M Krausová, D Braun… - Annual Review of …, 2023 - annualreviews.org
Early human life is considered a critical window of susceptibility to external exposures.
Infants are exposed to a multitude of environmental factors, collectively referred to as the …
Infants are exposed to a multitude of environmental factors, collectively referred to as the …
Drug-drug interactions that alter the exposure of glucuronidated drugs: Scope, UDP-glucuronosyltransferase (UGT) enzyme selectivity, mechanisms (inhibition and …
Drug-drug interactions (DDIs) arising from the perturbation of drug metabolising enzyme
activities represent both a clinical problem and a potential economic loss for the …
activities represent both a clinical problem and a potential economic loss for the …
Toward a consensus on applying quantitative liquid chromatography‐tandem mass spectrometry proteomics in translational pharmacology research: a white paper
Quantitative translation of information on drug absorption, disposition, receptor engagement,
and drug–drug interactions from bench to bedside requires models informed by …
and drug–drug interactions from bench to bedside requires models informed by …
Deep multi-view contrastive learning for cancer subtype identification
W Chen, H Wang, C Liang - Briefings in Bioinformatics, 2023 - academic.oup.com
Cancer heterogeneity has posed great challenges in exploring precise therapeutic
strategies for cancer treatment. The identification of cancer subtypes aims to detect patients …
strategies for cancer treatment. The identification of cancer subtypes aims to detect patients …
Metabolism and pharmacokinetic drug–drug interaction profile of vericiguat, a soluble guanylate cyclase stimulator: results from Preclinical and Phase I Healthy …
M Boettcher, M Gerisch, M Lobmeyer, N Besche… - Clinical …, 2020 - Springer
Background Vericiguat is a stimulator of soluble guanylate cyclase currently under
investigation as a first-in-class therapy for worsening chronic heart failure (NCT02861534) …
investigation as a first-in-class therapy for worsening chronic heart failure (NCT02861534) …