[HTML][HTML] The molecular activity of cannabidiol in the regulation of Nrf2 system interacting with NF-κB pathway under oxidative stress

SA Ekiner, A Gęgotek, E Skrzydlewska - Redox Biology, 2022 - Elsevier
Cannabidiol (CBD), the major non-psychoactive phytocannabinoid of Cannabis sativa L., is
one of the most studied compounds in pharmacotherapeutic approaches to treat oxidative …

Kinases control of regulated cell death revealing druggable targets for Parkinson's disease

HM Mansour, AF Mohamed, AS El-Khatib… - Ageing Research …, 2023 - Elsevier
Parkinson's disease (PD) is the second most prevalent neurodegenerative disorder in the
world. Motor impairment seen in PD is associated with dopaminergic neurotoxicity in the …

Therapeutic properties of multi-cannabinoid treatment strategies for Alzheimer's disease

M Coles, GZ Steiner-Lim, T Karl - Frontiers in Neuroscience, 2022 - frontiersin.org
Alzheimer's disease (AD) is a debilitating neurodegenerative disease characterized by
declining cognition and behavioral impairment, and hallmarked by extracellular amyloid-β …

Dual-acting small molecules: subtype-selective cannabinoid receptor 2 agonist/butyrylcholinesterase inhibitor hybrids show neuroprotection in an Alzheimer's disease …

P Spatz, SAM Steinmüller, A Tutov… - Journal of Medicinal …, 2023 - ACS Publications
We present the synthesis and characterization of merged human butyrylcholinesterase (h
BChE) inhibitor/cannabinoid receptor 2 (h CB2R) ligands for the treatment of …

Anti-microbial activity of phytocannabinoids and endocannabinoids in the light of their physiological and pathophysiological roles

RV Sionov, D Steinberg - Biomedicines, 2022 - mdpi.com
Antibiotic resistance has become an increasing challenge in the treatment of various
infectious diseases, especially those associated with biofilm formation on biotic and abiotic …

The mechanism of ferroptosis and its related diseases

S Feng, D Tang, Y Wang, X Li, H Bao, C Tang… - Molecular …, 2023 - Springer
Ferroptosis, a regulated form of cellular death characterized by the iron-mediated
accumulation of lipid peroxides, provides a novel avenue for delving into the intersection of …

The neuroprotective flavonoids sterubin and fisetin maintain mitochondrial health under oxytotic/ferroptotic stress and improve bioenergetic efficiency in HT22 …

M Goujon, Z Liang, D Soriano-Castell, A Currais… - Antioxidants, 2024 - mdpi.com
The global increase in the aging population has led to a rise in many age-related diseases
with continuing unmet therapeutic needs. Research into the molecular mechanisms …

[HTML][HTML] Fragment-based drug discovery and biological evaluation of novel cannabinol-based inhibitors of oxytosis/ferroptosis for neurological disorders

Z Liang, A Candib, D Soriano-Castell, W Fischer… - Redox Biology, 2024 - Elsevier
The oxytosis/ferroptosis regulated cell death pathway is an emerging field of research owing
to its pathophysiological relevance to a wide range of neurological disorders, including …

[HTML][HTML] Health benefits, pharmacological properties, and metabolism of cannabinol: A comprehensive review

A Khouchlaa, S Khouri, A Hajib, I Zeouk… - Industrial Crops and …, 2024 - Elsevier
Cannabinol (CBN) is a non-psychoactive phytocannabinoid found in Cannabis sativa.
Although overshadowed by its more well-known counterparts, such as delta-9 …

Transcriptome Highlights Cannabinol Modulation of Mitophagy in a Parkinson's Disease In Vitro Model

A Gugliandolo, S Blando, S Salamone, F Pollastro… - Biomolecules, 2023 - mdpi.com
Parkinson's disease (PD) is a neurodegenerative disorder characterized by the loss of
dopaminergic neurons in the substantia nigra and the accumulation of α-synuclein …