Emerging nanotechnology-based therapeutics to combat multidrug-resistant cancer
Cancer often develops multidrug resistance (MDR) when cancer cells become resistant to
numerous structurally and functionally different chemotherapeutic agents. MDR is …
numerous structurally and functionally different chemotherapeutic agents. MDR is …
Nanoparticle-based drug delivery systems in cancer: A focus on inflammatory pathways
It has become necessary to accept the clinical reality of therapeutic agents targeting the
cancer-associated immune system. In recent decades, several investigations have …
cancer-associated immune system. In recent decades, several investigations have …
EGFR targeted albumin nanoparticles of oleanolic acid: In silico screening of nanocarrier, cytotoxicity and pharmacokinetics for lung cancer therapy
This study aimed to develop cetuximab (CTX) functionalized albumin nanoparticles (ALB-
NPs) of oleanolic acid for EGFR targeted lung cancer therapy. The molecular docking …
NPs) of oleanolic acid for EGFR targeted lung cancer therapy. The molecular docking …
Silver nitroprusside nanoparticles for breast cancer therapy: in vitro and in vivo approach
The advancement of nanotechnology has led to the experimental development of cancer
therapeutics, which may overcome the shortcomings of commercially available drugs and …
therapeutics, which may overcome the shortcomings of commercially available drugs and …
Treatment of human glioblastoma U251 cells with sulforaphane and a peptide nucleic acid (PNA) targeting miR-15b-5p: synergistic effects on induction of apoptosis
Glioblastoma multiforme (GBM) is a lethal malignant tumor accounting for 42% of the tumors
of the central nervous system, the median survival being 15 months. At present, no curative …
of the central nervous system, the median survival being 15 months. At present, no curative …
A review on graph neural networks for predicting synergistic drug combinations
M Besharatifard, F Vafaee - Artificial Intelligence Review, 2024 - Springer
Combinational therapies with synergistic effects provide a powerful treatment strategy for
tackling complex diseases, particularly malignancies. Discovering these synergistic …
tackling complex diseases, particularly malignancies. Discovering these synergistic …
Drug delivery of 6-bromoindirubin-3'-glycerol-oxime ether employing poly(d,l-lactide-co-glycolide)-based nanoencapsulation techniques with sustainable solvents
A Czapka, C Grune, P Schädel, V Bachmann… - Journal of …, 2022 - Springer
Background Insufficient solubility and stability of bioactive small molecules as well as poor
biocompatibility may cause low bioavailability and are common obstacles in drug …
biocompatibility may cause low bioavailability and are common obstacles in drug …
Doxorubicin loaded thermostable nanoarchaeosomes: a next-generation drug carrier for breast cancer therapeutics
KV Babunagappan, A Seetharaman, S Ariraman… - Nanoscale …, 2024 - pubs.rsc.org
Breast cancer has a poor prognosis due to the toxic side effects associated with high doses
of chemotherapy. Liposomal drug encapsulation has resulted in clinical success in …
of chemotherapy. Liposomal drug encapsulation has resulted in clinical success in …
Ovalbumin-coated Fe 3 O 4 nanoparticles as a nanocarrier for chlorogenic acid to promote the anticancer efficacy on MDA-MB-231 cells
P Manivel, M Paulpandi, X Chen - New Journal of Chemistry, 2022 - pubs.rsc.org
Chlorogenic acid (5-CQA), a phenolic acid abundant in plants and herbs, has various
beneficial effects on human health. However, 5-CQA undergoes biotransformation during …
beneficial effects on human health. However, 5-CQA undergoes biotransformation during …
Craft of co-encapsulation in nanomedicine: a struggle to achieve synergy through reciprocity
S Bhattacharjee - ACS Pharmacology & Translational Science, 2022 - ACS Publications
Achieving synergism, often by combination therapy via codelivery of chemotherapeutic
agents, remains the mainstay of treating multidrug-resistance cases in cancer and microbial …
agents, remains the mainstay of treating multidrug-resistance cases in cancer and microbial …