Dopamine regulates reward-related behavior through the mesolimbic dopaminergic
pathway. Stress affects dopamine levels and dopaminergic neuronal activity in the …

This review paper provides an integrative account regarding neurophysiological correlates
of positive emotions and affect that cumulatively contribute to the scaffolding for positive …

Psychedelics have inspired new hope for treating brain disorders, as they seem to be unlike
any treatments currently available. Not only do they produce sustained therapeutic effects …

Sex differences have been observed across many psychiatric diseases, especially mood
disorders. For major depression, the most prevalent psychiatric disorder, females show a …

Rationale The chronic mild stress (CMS) paradigm was first described almost 40 years ago
and has become a widely used model in the search for antidepressant drugs for major …

Depression is a complex disorder that takes an enormous toll on individual health. As
affected individuals display a wide variation in their clinical symptoms, the precise neural …

Ketamine is the prototype for a new generation of glutamate-based antidepressants that
rapidly alleviate depression within hours of treatment. Over the past decade, there has been …

Anhedonia, or the loss of pleasure in previously rewarding stimuli, is a core symptom of
major depressive disorder that may reflect an underlying dysregulation in reward …

Abstract Background The nucleus accumbens (NAc) is an important region in reward circuit
that has been linked with anhedonia, which is a characteristic symptom of major depressive …

Major depressive disorder (MDD) is a common psychiatric disorder effecting approximately
121 million people worldwide and recent reports from the World Health Organization (WHO) …