Circulation. 2017; 136: 680–686. DOI: 10.1161/CIRCULATIONAHA. 117.029343 August 15,
2017 681 proliferation. 5 It remains unclear whether this regenerative window exists in large …

The extracellular matrix (ECM) is an essential component of the heart that imparts
fundamental cellular processes during organ development and homeostasis. Most …

We recently identified a brief time period during postnatal development when the
mammalian heart retains significant regenerative potential after amputation of the ventricular …

Adult stem cells are fundamental to maintain tissue homeostasis, growth, and regeneration.
They reside in specialized environments called niches. Following activating signals, they …

If and how the heart regenerates after an injury event is highly debated. c-kit-expressing
cardiac progenitor cells have been reported as the primary source for generation of new …

Macrophages are ubiquitous cells that reside in all major tissues. Counter to long-held
beliefs, we now know that resident macrophages in many organs are seeded during …

Identifying a bona fide population of cardiac stem cells (CSCs) is a critical step for
developing cell-based therapies for heart failure patients. Previously, cardiac c-kit+ cells …

Adult humans fail to regenerate their hearts following injury, and this failure to regenerate
myocardium is a leading cause of heart failure and death worldwide. Although all adult …

Despite improvements in modern cardiovascular therapy, the morbidity and mortality of
ischaemic heart disease (IHD) and heart failure (HF) remain significant in Europe and …

The significance of cardiac stem cell (CSC) populations for cardiac regeneration remains
disputed. Here, we apply the most direct definition of stem cell function (the ability to replace …