In the peripheral nervous system, Schwann cells are glial cells that are in intimate contact
with axons throughout development. Schwann cells generate the insulating myelin sheath …

Dedifferentiation of myelinating Schwann cells is a key feature of nerve injury and
demyelinating neuropathies. We review recent evidence that this dedifferentiation depends …

The etiology and pathophysiology of schizophrenia remain unknown. A parallel
transcriptomics, proteomics and metabolomics approach was employed on human brain …

The pathogenesis of incipient Alzheimer's disease (AD) has been resistant to analysis
because of the complexity of AD and the overlap of its early-stage markers with normal …

The transcriptional control of CNS myelin gene expression is poorly understood. Here we
identify gene model 98, which we have named myelin gene regulatory factor (MRF), as a …

Gene expression microarrays provide a powerful new tool for studying complex processes
such as brain aging. However, inferences from microarray data are often hindered by …

Abstract Peripheral myelin protein-22 (PMP22) is primarily expressed in the compact myelin
of the peripheral nervous system. Levels of PMP22 have to be tightly regulated since …

Mutations in the mitochondrial fusion protein mitofusin 2 (MFN2) are the most commonly
identified cause of Charcot-Marie-Tooth type 2 (CMT2), a dominantly inherited disease …

Schwann cell myelination depends on Krox-20/Egr2 and other promyelin transcription
factors that are activated by axonal signals and control the generation of myelin-forming …

Mitochondrial dysfunction is a common cause of peripheral neuropathy. Much effort has
been devoted to examining the role played by neuronal/axonal mitochondria, but how …