Dopamine, immunity, and disease

B Channer, SM Matt, EA Nickoloff-Bybel, V Pappa… - Pharmacological …, 2023 - Elsevier
The neurotransmitter dopamine is a key factor in central nervous system (CNS) function,
regulating many processes including reward, movement, and cognition. Dopamine also …

Microglia mediated neuroinflammation in Parkinson's disease

S Isik, B Yeman Kiyak, R Akbayir, R Seyhali, T Arpaci - Cells, 2023 - mdpi.com
Parkinson's Disease (PD) is the second most common neurodegenerative disorder seen,
especially in the elderly. Tremor, shaking, movement problems, and difficulty with balance …

The progress of gut microbiome research related to brain disorders

S Zhu, Y Jiang, K Xu, M Cui, W Ye, G Zhao… - Journal of …, 2020 - Springer
There is increasing evidence showing that the dynamic changes in the gut microbiota can
alter brain physiology and behavior. Cognition was originally thought to be regulated only by …

Effect of high-fat diets on oxidative stress, cellular inflammatory response and cognitive function

BL Tan, ME Norhaizan - Nutrients, 2019 - mdpi.com
Cognitive dysfunction is linked to chronic low-grade inflammatory stress that contributes to
cell-mediated immunity in creating an oxidative environment. Food is a vitally important …

[HTML][HTML] Acupuncture inhibits neuroinflammation and gut microbial dysbiosis in a mouse model of Parkinson's disease

JH Jang, MJ Yeom, S Ahn, JY Oh, S Ji, TH Kim… - Brain, Behavior, and …, 2020 - Elsevier
Growing evidences show that gut microbiota is associated with the pathogenesis of
Parkinson's disease (PD) and the gut-brain axis can be promising target for the development …

[HTML][HTML] Brain-gut-microbiota axis in Parkinson's disease

A Mulak, B Bonaz - World journal of gastroenterology: WJG, 2015 - ncbi.nlm.nih.gov
Parkinson's disease (PD) is characterized by alpha-synucleinopathy that affects all levels of
the brain-gut axis including the central, autonomic, and enteric nervous systems. Recently, it …

Gut microbiome in health and disease: Linking the microbiome–gut–brain axis and environmental factors in the pathogenesis of systemic and neurodegenerative …

S Ghaisas, J Maher, A Kanthasamy - Pharmacology & therapeutics, 2016 - Elsevier
The gut microbiome comprises the collective genome of the trillions of microorganisms
residing in our gastrointestinal ecosystem. The interaction between the host and its gut …

Neuroinflammation in Parkinson's disease and its potential as therapeutic target

Q Wang, Y Liu, J Zhou - Translational neurodegeneration, 2015 - Springer
Abstract Parkinson's disease (PD), the second most common age-associated
neurodegenerative disorder, is characterized by the loss of dopaminergic (DA) neurons and …

Brain and peripheral atypical inflammatory mediators potentiate neuroinflammation and neurodegeneration

D Kempuraj, R Thangavel, GP Selvakumar… - Frontiers in cellular …, 2017 - frontiersin.org
Neuroinflammatory response is primarily a protective mechanism in the brain. However,
excessive and chronic inflammatory responses can lead to deleterious effects involving …

Unhealthy gut, unhealthy brain: The role of the intestinal microbiota in neurodegenerative diseases

LJ Spielman, DL Gibson, A Klegeris - Neurochemistry international, 2018 - Elsevier
The number of bacterial cells living within the human body is approximately equal to, or
greater than, the total number of human cells. This dynamic population of microorganisms …