Despite the long-standing observation of vast neuronal loss in Alzheimer's disease (AD) our
understanding of how and when neurons are eliminated is incomplete. While previous …

Ferroptosis is a recently identified, iron-regulated, non-apoptotic form of cell death. It is
characterized by cellular accumulation of lipid reactive oxygen species that ultimately leads …

Synaptic loss and neuron death are the underlying cause of neurodegenerative diseases
such as Alzheimer's disease (AD); however, the modalities of cell death in those diseases …

Apoptosis is an intrinsic biochemical, cellular process that regulates cell death and is crucial
for cell survival, cellular homeostasis, and maintaining the optimum functional status …

Increasing the lifespan of a population is often a marker of a country's success. With the
percentage of the population over 65 yr of age expanding, managing the health and …

Alzheimer's disease (AD) is hallmarked by amyloid plaques, neurofibrillary tangles, and
widespread cortical neuronal loss. The “amyloid cascade hypothesis” posits that cerebral …

Alzheimer Disease (AD) is a neurodegenerative disorder and the most common form of
dementia. Histopathologically is characterized by the presence of two major hallmarks, the …

Modern research has provided new in-sights into the biological mechanisms of noise-
induced hearing loss, and with these new insights comes hope for possible prevention or …

Most histories of senile dementia commence with Alois Alzheimer's description in 1906 of
the first case of Alzheimer's disease, yet the history of senile dementia before 1906 is quite …

beta-Amyloid precursor protein (beta-APP), the source of the fibrillogenic amyloid beta-
peptide (A beta) that accumulates in the brain of victims of Alzheimer's disease, is a …