Glioblastoma multiforme (GBM) is the most common and malignant of the glial tumors. The
world-wide estimates of new cases and deaths annually are remarkable, making GBM a …

The volume-regulated anion channel (VRAC) is a key player in the volume regulation of
vertebrate cells. This ubiquitously expressed channel opens upon osmotic cell swelling and …

Glioblastoma (GBM), the most lethal form of brain tumors, bases its malignancy on the strong
ability of its cells to migrate and invade the narrow spaces of healthy brain parenchyma. Cell …

Regulatory volume decrease (RVD), a homeostatic process responsible for the re‐
establishment of the original cell volume upon swelling, is critical in controlling several …

The malignancy of glioblastoma (GBM), the most aggressive type of human brain tumor,
strongly correlates with the presence of hypoxic areas within the tumor mass. Oxygen levels …

All cells are capable of secreting extracellular vesicles (EVs), which are not a means to
eliminate unneeded cellular compounds but represent a process to exchange material …

Brain tumors come in many types and differ greatly in outcome. They are classified by the
cell of origin (astrocytoma, ependymoma, meningioma, medulloblastoma, glioma), although …

Astrocytes, the main glial cells of the central nervous system, play a key role in brain volume
control due to their intimate contacts with cerebral blood vessels and the expression of a …

Glioblastomas (GBMs) are brain tumors characterized by diffuse invasion of cancer cells into
the healthy brain parenchyma, and establishment of secondary foci. GBM cells abundantly …

Cisplatin [cis-diamminedichloroplatinum (II)] is a platinum-based anticancer drug widely
used for the treatment of various cancers. It forms interstrand and intrastrand cross-linking …