Colorectal cancer (CRC), one of the most common and deadliest diseases worldwide, poses
a great health threat and social burden. The clinical treatments of CRC encompassing …

The critical role of tumor microenvironment (TME) in tumor initiation and development has
been well-recognized after more than a century of studies. Numerous therapeutic …

FOLFOX, the combinational strategy of folinic acid (FnA), 5-fluorouracil (5-Fu), and
oxaliplatin (OxP), has been used as standard treatment of colorectal cancer (CRC) for …

Background FOLFOX is a combinational regimen of folinic acid (FnA, FOL), fluorouracil (5-
Fu, F) and oxaliplatin (OxP, OX), and has been long considered as the standard treatment of …

Activation of the hepatic stellate cells (HSCs) is a key pathogenic event in liver fibrosis.
Protein S-glutathionylation (PSSG) of cysteine residues is a distinct form of oxidative …

The antitumor immune response of cancer immunotherapy is a cascade of cancer–immunity
cycles (CIC). The immunosuppression of the tumor microenvironment and low …

Hepatocellular carcinoma (HCC) causes the immunosuppressive tumor microenvironment
(TME) resistant to current immunotherapy. The immunogenic apoptosis (currently termed …

Tumor-associated macrophages play pivotal roles in tumor progression and metastasis.
Macrophage-mediated clearance of apoptotic cells (efferocytosis) supports inflammation …

Activation of extracellular matrix–producing hepatic stellate cells (HSCs) is a key event in
liver fibrogenesis. We showed that the expression of the heme-thiolate monooxygenase …

The investigation into relaxin (RLN), additional RLN-like proteins, and RLN family peptide
receptors (RXFP) has demonstrated their role in modulating the extracellular matrix (ECM) …