Paradigm shift: new concepts for HCN4 function in cardiac pacemaking
Hyperpolarization-activated cyclic nucleotide–gated (HCN) channels are the molecular
correlate of the If current and are critically involved in controlling neuronal excitability and …
correlate of the If current and are critically involved in controlling neuronal excitability and …
Ih from synapses to networks: HCN channel functions and modulation in neurons
CL Combe, S Gasparini - Progress in biophysics and molecular biology, 2021 - Elsevier
Hyperpolarization-activated cyclic nucleotide gated (HCN) channels and the current they
carry, I h, are widely and diversely distributed in the central nervous system (CNS). The …
carry, I h, are widely and diversely distributed in the central nervous system (CNS). The …
Engineering a K+ channel 'sensory antenna' enhances stomatal kinetics, water use efficiency and photosynthesis
Stomata of plant leaves open to enable CO2 entry for photosynthesis and close to reduce
water loss via transpiration. Compared with photosynthesis, stomata respond slowly to …
water loss via transpiration. Compared with photosynthesis, stomata respond slowly to …
A gain-of-function HCN4 mutant in the HCN domain is responsible for inappropriate sinus tachycardia in a Spanish family
A Cámara-Checa, F Perin… - Proceedings of the …, 2023 - National Acad Sciences
In a family with inappropriate sinus tachycardia (IST), we identified a mutation (p. V240M) of
the hyperpolarization-activated cyclic nucleotide–gated type 4 (HCN4) channel, which …
the hyperpolarization-activated cyclic nucleotide–gated type 4 (HCN4) channel, which …
Gating movements and ion permeation in HCN4 pacemaker channels
The HCN1–4 channel family is responsible for the hyperpolarization-activated cation current
I f/I h that controls automaticity in cardiac and neuronal pacemaker cells. We present …
I f/I h that controls automaticity in cardiac and neuronal pacemaker cells. We present …
Biophysical analysis of an HCN1 epilepsy variant suggests a critical role for S5 helix Met-305 in voltage sensor to pore domain coupling
A Hung, IC Forster, CE Mckenzie, G Berecki… - Progress in Biophysics …, 2021 - Elsevier
Hyperpolarization-gated, cyclic nucleotide-activated (HCN1-4) channels are inwardly
rectifying cation channels that display voltage dependent activation and de-activation …
rectifying cation channels that display voltage dependent activation and de-activation …
Compartmentalized cAMP signalling and control of cardiac rhythm
J Tomek, M Zaccolo - Philosophical Transactions of the …, 2023 - royalsocietypublishing.org
In the last 30 years, the field of cyclic adenosine 3′, 5′-monophosphate (cAMP) signalling
has witnessed a transformative development with the realization that cAMP is …
has witnessed a transformative development with the realization that cAMP is …
Alternative targets for modulators of mitochondrial potassium channels
A Wrzosek, S Gałecka, M Żochowska, A Olszewska… - Molecules, 2022 - mdpi.com
Mitochondrial potassium channels control potassium influx into the mitochondrial matrix and
thus regulate mitochondrial membrane potential, volume, respiration, and synthesis of …
thus regulate mitochondrial membrane potential, volume, respiration, and synthesis of …
Computation of the protein conformational transition pathway on ligand binding by linear response-driven molecular dynamics
While extremely important for relating the protein structure to its biological function,
determination of the protein conformational transition pathway upon ligand binding is made …
determination of the protein conformational transition pathway upon ligand binding is made …
Structural and functional approaches to studying cAMP regulation of HCN channels
Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are primarily activated
by voltage and further modulated by cAMP. While cAMP binding alone does not open the …
by voltage and further modulated by cAMP. While cAMP binding alone does not open the …