Detergents are widely used for membrane protein solubilization, purification, and structural
analysis. Over the past two decades, much effort has been made to design novel detergents …

Integral membrane proteins (MPs) are important drug targets across most fields of medicine,
but historically have posed a major challenge for drug discovery due to difficulties in …

The mechanosensitive channel of small conductance (MscS) protects bacteria against
hypoosmotic shock. It can sense the tension in the surrounding membrane and releases …

Membrane protein purification by means of detergents is key to isolating membrane‐bound
therapeutic targets. The role of the detergent structure in this process, however, is not well …

Over the past decade, the vast amount of information generated through structural and
biophysical studies of GPCRs has provided unprecedented mechanistic insight into the …

Much hope in drug development comes from the discovery of positive allosteric modulators
(PAM) that display target subtype selectivity and act by increasing agonist potency and …

Understanding the roles of intermediate states in signaling is pivotal to unraveling the
activation processes of G protein-coupled receptors (GPCRs). However, the field is still …

The first member and eponym of the rhodopsin family was identified in the 1930s as the
visual pigment of the rod photoreceptor cell in the animal retina. It was found to be a …

Multicomponent transporters are used by bacteria to transport a wide range of nutrients.
These systems use a substrate-binding protein to bind the nutrient with high affinity and then …

Single-particle cryo-electron microscopy (cryo-EM SPA) has recently emerged as an
exceptionally well-suited technique for determining the structure of membrane proteins …