The road to elimination: current state of schistosomiasis research and progress towards the end game

P Ogongo, RK Nyakundi, GK Chege… - Frontiers in …, 2022 - frontiersin.org
The new WHO Roadmap for Neglected Tropical Diseases targets the global elimination of
schistosomiasis as a public health problem. To date, control strategies have focused on …

Pattern recognition receptor signaling and innate immune responses to schistosome infection

N Dibo, X Liu, Y Chang, S Huang, X Wu - Frontiers in Cellular and …, 2022 - frontiersin.org
Schistosomiasis remains to be a significant public health problem in tropical and subtropical
regions. Despite remarkable progress that has been made in the control of the disease over …

Schistosoma mansoni vaccine candidates identified by unbiased phage display screening in self-cured rhesus macaques

D Woellner-Santos, AC Tahira, JVM Malvezzi, V Mesel… - npj Vaccines, 2024 - nature.com
Schistosomiasis, a challenging neglected tropical disease, affects millions of people
worldwide. Developing a prophylactic vaccine against Schistosoma mansoni has been …

Functional genomics in Spiralia

FM Martín-Zamora, BE Davies… - Briefings in …, 2023 - academic.oup.com
Our understanding of the mechanisms that modulate gene expression in animals is strongly
biased by studying a handful of model species that mainly belong to three groups: Insecta …

Development of lateral flow assays to detect host proteins in cattle for improved diagnosis of bovine tuberculosis

H Khalid, L Pierneef, A Van Hooij, Z Zhou… - Frontiers in Veterinary …, 2023 - frontiersin.org
Bovine tuberculosis (bTB), caused by Mycobacterium bovis (M. bovis) infection in cattle, is
an economically devastating chronic disease for livestock worldwide. Efficient disease …

A low dose adenovirus vectored vaccine expressing Schistosoma mansoni Cathepsin B protects from intestinal schistosomiasis in mice

DJ Perera, AS Hassan, SS Liu, SM Elahi, C Gadoury… - …, 2022 - thelancet.com
Background Schistosomiasis is an underestimated neglected tropical disease which affects
over 236.6 million people worldwide. According to the CDC, the impact of this disease is …

Models of Protective Immunity against Schistosomes: Implications for Vaccine Development

RA Wilson - Pathogens, 2023 - mdpi.com
After many decades of research, a schistosome vaccine still looks to be a distant prospect.
These helminths can live in the human bloodstream for years, even decades, surrounded by …

Antigenic epitope targets of rhesus macaques self-curing from Schistosoma mansoni infection

GM Vance, MI Khouri, APS Neto, S James… - Frontiers in …, 2024 - frontiersin.org
The self-cure of rhesus macaques from a schistosome infection and their subsequent strong
immunity to a cercarial challenge should provide novel insights into the way these parasites …

Salmonella Typhimurium expressing chromosomally integrated Schistosoma mansoni Cathepsin B protects against schistosomiasis in mice

AS Hassan, S Houle, L Labrie, DJ Perera, CM Dozois… - npj Vaccines, 2023 - nature.com
Schistosomiasis threatens hundreds of millions of people worldwide. The larval stage of
Schistosoma mansoni migrates through the lung and adult worms reside adjacent to the …

Long Non-Coding RNA Levels Are Modulated in Schistosoma mansoni following In Vivo Praziquantel Exposure

P Jardim Poli, A Fischer-Carvalho, AC Tahira… - Non-coding RNA, 2024 - mdpi.com
Schistosomiasis is a disease caused by trematodes of the genus Schistosoma that affects
over 200 million people worldwide. For decades, praziquantel (PZQ) has been the only …