Muscle cells are designed to generate force and movement. There are three types of
mammalian muscles—skeletal, cardiac, and smooth. Skeletal muscles are attached to …

The progress made in our understanding of the pathophysiology and treatment of
congestive heart failure (CHF) would not have been possible without a number of animal …

The most common form of genetic heart disease is hypertrophic cardiomyopathy (HCM),
which is caused by variants in cardiac sarcomeric genes and leads to abnormal heart …

Familial hypertrophic cardiomyopathy (HCM) is a prevalent hereditary cardiac disorder
linked to arrhythmia and sudden cardiac death. While the causes of HCM have been …

We have derived a cardiac muscle cell line, designated HL-1, from the AT-1 mouse atrial
cardiomyocyte tumor lineage. HL-1 cells can be serially passaged, yet they maintain the …

Nearly one-third of deaths in the United States are caused by cardiovascular disease (CVD)
each year. In the past, CVD was thought to mainly affect men, leading to the exclusion of …

Using quantitative RT-PCR in RNA from right ventricular (RV) endomyocardial biopsies from
intact nonfailing hearts, and subjects with moderate RV failure from primary pulmonary …

The cardiac ventricular myosin phenotype is developmentally and hormonally regulated.
The genes coding for the two myosin heavy chains (MHCs), alpha and beta, have been …

The intergenic region between the mouse alpha-myosin heavy chain (MHC) and beta-MHC
genes was analyzed in terms of its ability to drive gene expression in transgenic mice …

To determine the effects of age on the myocardium, the functional and structural
characteristics of the heart were studied in rats at 4, 12, 20, and 29 months of age. Mean …