Neurological adverse events of immune checkpoint inhibitors: an update of clinical presentations, diagnosis, and management

A Farina, M Villagrán-García, J Honnorat - Revue Neurologique, 2023 - Elsevier
The use of immune checkpoint inhibitors (ICIs) has represented a major advance in cancer
treatment. By enhancing endogenous immune responses to destroy cancer cells, ICIs can …

Neurotoxicity and safety of the rechallenge of immune checkpoint inhibitors: a growing issue in neuro-oncology practice

M Villagrán-García, R Velasco - Neurological Sciences, 2022 - Springer
Neurological, immune-related adverse events (n-irAE) due to immune checkpoint inhibitors
(ICI) represent a growing clinical problem in neuro-oncology practice. Although rare, the …

Myasthenia gravis induced by immune checkpoint inhibitors: an emerging neurotoxicity in neuro-oncology practice: case series

C Marco, M Simó, M Alemany, C Casasnovas… - Journal of Clinical …, 2022 - mdpi.com
Immunotherapy with immune checkpoint inhibitors (ICIs) have been reported to induce de
novo or exacerbate pre-existing Myasthenia Gravis (MG). We present a single center case …

[HTML][HTML] Development of preclinical and clinical models for immune-related adverse events following checkpoint immunotherapy: a perspective from SITC and AACR

NL Bayless, JA Bluestone, S Bucktrout… - … for immunotherapy of …, 2021 - ncbi.nlm.nih.gov
Recent advances in cancer immunotherapy have completely revolutionized cancer
treatment strategies. Nonetheless, the increasing incidence of immune-related adverse …

Elaborating on anti CTLA-4 mechanisms of action using an agent-based modeling approach

I Azarov, G Helmlinger, Y Kosinsky… - Frontiers in Applied …, 2022 - frontiersin.org
Anti CTLA-4 therapy is aimed at blocking the Cytotoxic T-lymphocyte antigen-4 (CTLA-4), a
key cancer immunity cycle checkpoint. The mechanism of action of CTLA-4 may be …

Tofacitinib is effective in treating refractory immune checkpoint inhibitor hepatitis

M Wang, KL Reynolds, K Montazeri… - Clinical …, 2024 - cghjournal.org
Immune checkpoint inhibitors (ICI) have improved metastatic melanoma outcomes; however,
toxicities, such as hepatitis, can be dose-limiting or even fatal. 1 Systemic glucocorticoids …

Neurological Adverse Events Related to Immune Checkpoint Inhibitors: A Practical Review

F Zammit, E Seront - Pharmaceuticals, 2024 - mdpi.com
The increasing use of immune checkpoint inhibitors (ICI) in cancer therapy has brought
attention to their associated neurotoxicities, termed neurological immune-related adverse …

Immune-related adverse events requiring hospitalization in patients with lung cancer: implications and insights

A Falade, L Zubiri, CY Wu, K Perlman, J Sun… - The …, 2024 - academic.oup.com
Background Immune checkpoint inhibitors (ICI) are associated with a distinct spectrum of
toxicities. Data on irAE hospitalization rates and clinical course of patients with thoracic …

Outcomes of immune checkpoint inhibitor‐induced liver toxicity managed by hepatologists in a multidisciplinary toxicity team

T Ito, K Mizuno, T Yamamoto, T Yasuda… - Hepatology …, 2024 - Wiley Online Library
Aim To detect immune‐related adverse events (irAEs) early and treat them appropriately,
our institute established an irAE‐focused multidisciplinary toxicity team in cooperation with …

Practice Changes in Checkpoint Inhibitor-Induced Immune-Related Adverse Event Management at a Tertiary Care Center

M Shatila, F Eshaghi, AR Thomas, AG Kuang, JS Shah… - Cancers, 2024 - mdpi.com
Simple Summary Immune-related adverse events (irAEs) are becoming an increasingly
prevalent and well-studied phenomenon. Little is known about how clinical practice has …