Globally, colorectal cancer (CRC) is the third most commonly diagnosed malignancy and the
second leading cause of cancer death. Arising through three major pathways, including …

Gastric cancer (GC) is a leading contributor to global cancer incidence and mortality.
Pioneering genomic studies, focusing largely on primary GCs, revealed driver alterations in …

Hypertension is the most important modifiable cause of cardiovascular (CV) disease and all-
cause mortality worldwide. Despite the positive correlations between blood pressure (BP) …

Using genome-wide data of 89 ancient individuals dated to 5100 to 100 years before the
present (BP) from 29 sites across the Tibetan Plateau, we found plateau-specific ancestry …

Ischemic stroke is a leading cause of global mortality and long-term disability. However,
there is a paucity of whole-genome sequencing studies on ischemic stroke, resulting in …

BACKGROUND AND OBJECTIVES Esophageal Cancer (EC) is a lethal malignancy with
poor prognosis and significant variations in the incidence, mortality, and histopathology …

In preparation for a collaborative multidisciplinary study of the pathogenesis of esophageal
cancer, the authors reviewed the published literature to identify similarities and differences …

A family of detoxifying enzymes called aldehyde dehydrogenases (ALDHs) has been a
subject of recent interest, as its role in detoxifying aldehydes that accumulate through …

Background & Aims Excessive alcohol consumption is one of the major causes of
hepatocellular carcinoma (HCC). Approximately 30–40% of the Asian population are …

We conducted a meta-analysis of genome-wide association studies of systolic (SBP) and
diastolic (DBP) blood pressure in 19,608 subjects of east Asian ancestry from the AGEN-BP …