The great immune escape: understanding the divergent immune response in breast cancer subtypes

SS Onkar, NM Carleton, PC Lucas, TC Bruno, AV Lee… - Cancer discovery, 2023 - AACR
Breast cancer, the most common type of cancer affecting women, encompasses a collection
of histologic (mainly ductal and lobular) and molecular subtypes exhibiting diverse clinical …

Comprehensive molecular characterization of muscle-invasive bladder cancer

AG Robertson, J Kim, H Al-Ahmadie, J Bellmunt, G Guo… - Cell, 2017 - cell.com
We report a comprehensive analysis of 412 muscle-invasive bladder cancers characterized
by multiple TCGA analytical platforms. Fifty-eight genes were significantly mutated, and the …

The variety of 3D breast cancer models for the study of tumor physiology and drug screening

E Fröhlich - International Journal of Molecular Sciences, 2023 - mdpi.com
Breast cancer is the most common cancer in women and responsible for multiple deaths
worldwide. 3D cancer models enable a better representation of tumor physiology than the …

Proteomic analysis of archival breast cancer clinical specimens identifies biological subtypes with distinct survival outcomes

K Asleh, GL Negri, SE Spencer Miko… - Nature …, 2022 - nature.com
Despite advances in genomic classification of breast cancer, current clinical tests and
treatment decisions are commonly based on protein level information. Formalin-fixed …

Epigenetic reprogramming of cancer-associated fibroblasts deregulates glucose metabolism and facilitates progression of breast cancer

LM Becker, JT O'Connell, AP Vo, MP Cain, D Tampe… - Cell reports, 2020 - cell.com
The mechanistic contributions of cancer-associated fibroblasts (CAFs) in breast cancer
progression remain to be fully understood. While altered glucose metabolism in CAFs could …

Breast cancer quantitative proteome and proteogenomic landscape

HJ Johansson, F Socciarelli, NM Vacanti… - Nature …, 2019 - nature.com
In the preceding decades, molecular characterization has revolutionized breast cancer (BC)
research and therapeutic approaches. Presented herein, an unbiased analysis of breast …

Tumour stroma ratio assessment using digital image analysis predicts survival in triple negative and luminal breast cancer

EKA Millar, LH Browne, J Beretov, K Lee, J Lynch… - Cancers, 2020 - mdpi.com
Simple Summary Tumour stroma is known to predict outcome and play an important role in
the growth and spread of solid tumours and their response to therapy. In breast cancer, there …

Integrative clustering reveals a novel split in the luminal A subtype of breast cancer with impact on outcome

MR Aure, V Vitelli, S Jernström, S Kumar… - Breast Cancer …, 2017 - Springer
Background Breast cancer is a heterogeneous disease at the clinical and molecular level. In
this study we integrate classifications extracted from five different molecular levels in order to …

Immune and stroma related genes in breast cancer: a comprehensive analysis of tumor microenvironment based on the cancer genome atlas (TCGA) database

M Xu, Y Li, W Li, Q Zhao, Q Zhang, K Le… - Frontiers in …, 2020 - frontiersin.org
Background: Tumor microenvironment is essential for breast cancer progression and
metastasis. Our study sets out to examine the genes affecting stromal and immune infiltration …

Identification of a five‐lncRNA signature for predicting the risk of tumor recurrence in patients with breast cancer

J Li, W Wang, P Xia, L Wan, L Zhang… - … journal of cancer, 2018 - Wiley Online Library
Long non‐coding RNAs (lncRNAs) are a major class of non‐coding RNAs, and the
functional deregulations of lncRNAs have been shown to be associated with the …