Aging is a universal process of age-dependent physiological and functional declines that
are strongly associated with human diseases. Despite extensive studies of the molecular …

Oxidative metabolism declines with aging in humans leading to multiple metabolic ailments
and subsequent inflammation. In mice, there is evidence of age-related suppression of fatty …

Restricting the intake of protein or the branched-chain amino acid isoleucine promotes
healthspan and extends lifespan in young or adult mice. However, their effects when …

Health is strongly affected by aging and lifespan-modulating interventions, but the molecular
mechanisms of mortality regulation remain unclear. Here, we conducted an RNA-seq …

Phloretin has been widely perceived as an antioxidant. However, the bioavailability of
phloretin in vivo is generally far too low to elicit a direct antioxidant effect by scavenging …

In defiance of the paradigm that calories from all sources are equivalent, we and others have
shown that dietary protein is a dominant regulator of healthy aging. The restriction of protein …

Genetically heterogeneous UM-HET3 mice born in 2020 were used to test possible lifespan
effects of alpha-ketoglutarate (AKG), 2, 4-dinitrophenol (DNP), hydralazine (HYD), nebivolol …

Early nutrition has significant effects on physiological outcomes during adult life. We have
analysed the effect of maternal α-casein (CSN1S1) deficiency on the physiological fate of …

17α-estradiol (17α-E2) is a naturally occurring nonfeminizing diastereomer of 17β-estradiol
that has life span-extending effects in rodent models. To date, studies of the systemic and …

A growing number of geroprotectors have demonstrated healthspan extension in young
animals, but the effectiveness of these therapies when commenced in midlife or later has …