Phenotypic heterogeneity in persisters: a novel 'hunker'theory of persistence
J Urbaniec, Y Xu, Y Hu… - FEMS microbiology …, 2022 - academic.oup.com
Persistence has been linked to treatment failure since its discovery over 70 years ago and
understanding formation, nature and survival of this key antibiotic refractory subpopulation is …
understanding formation, nature and survival of this key antibiotic refractory subpopulation is …
Emergent simplicities in the living histories of individual cells
Organisms maintain the status quo, holding key physiological variables constant to within an
acceptable tolerance, and yet adapt with precision and plasticity to dynamic changes in …
acceptable tolerance, and yet adapt with precision and plasticity to dynamic changes in …
DeLTA 2.0: A deep learning pipeline for quantifying single-cell spatial and temporal dynamics
Improvements in microscopy software and hardware have dramatically increased the pace
of image acquisition, making analysis a major bottleneck in generating quantitative, single …
of image acquisition, making analysis a major bottleneck in generating quantitative, single …
Bacteriostatic antibiotics promote CRISPR-Cas adaptive immunity by enabling increased spacer acquisition
Phages impose strong selection on bacteria to evolve resistance against viral predation.
Bacteria can rapidly evolve phage resistance via receptor mutation or using their CRISPR …
Bacteria can rapidly evolve phage resistance via receptor mutation or using their CRISPR …
Persister Escherichia coli cells have a lower intracellular pH than susceptible cells but maintain their pH in response to antibiotic treatment
Persister and viable but non-culturable (VBNC) cells are two clonal subpopulations that can
survive multidrug exposure via a plethora of putative molecular mechanisms. Here, we …
survive multidrug exposure via a plethora of putative molecular mechanisms. Here, we …
Host cell oxidative stress induces dormant Staphylococcus aureus persisters
F Peyrusson, TK Nguyen, T Najdovski… - Microbiology …, 2022 - Am Soc Microbiol
Persisters are transiently nongrowing and antibiotic-tolerant phenotypic variants identified in
major human pathogens, including intracellular Staphylococcus aureus. Due to their …
major human pathogens, including intracellular Staphylococcus aureus. Due to their …
Fast bacterial growth reduces antibiotic accumulation and efficacy
Phenotypic variations between individual microbial cells play a key role in the resistance of
microbial pathogens to pharmacotherapies. Nevertheless, little is known about cell …
microbial pathogens to pharmacotherapies. Nevertheless, little is known about cell …
Slow growing bacteria survive bacteriophage in isolation
EL Attrill, U Łapińska, ER Westra… - ISME …, 2023 - academic.oup.com
The interactions between bacteria and bacteriophage have important roles in the global
ecosystem; in turn changes in environmental parameters affect the interactions between …
ecosystem; in turn changes in environmental parameters affect the interactions between …
Single-cell microfluidics facilitates the rapid quantification of antibiotic accumulation in Gram-negative bacteria
The double-membrane cell envelope of Gram-negative bacteria is a formidable barrier to
intracellular antibiotic accumulation. A quantitative understanding of antibiotic transport in …
intracellular antibiotic accumulation. A quantitative understanding of antibiotic transport in …
Systematic comparison of unilamellar vesicles reveals that archaeal core lipid membranes are more permeable than bacterial membranes
U Łapińska, G Glover, Z Kahveci, NAT Irwin… - PLoS …, 2023 - journals.plos.org
One of the deepest branches in the tree of life separates the Archaea from the Bacteria.
These prokaryotic groups have distinct cellular systems including fundamentally different …
These prokaryotic groups have distinct cellular systems including fundamentally different …