When animals walk overground, mechanical stimuli activate various receptors located in
muscles, joints and skin. Afferents from these mechanoreceptors project to neuronal …

Chemotherapy agents used in the standard treatments for many types of cancer are
neurotoxic and can lead to lasting sensory and motor symptoms that compromise day-to-day …

Despite decades of research, we lack a mechanistic framework capable of predicting how
movement-related signals are transformed into the diversity of muscle spindle afferent firing …

Key points Muscle spindle afferents are slowly adapting low threshold mechanoreceptors
that report muscle length and movement information critical for motor control and …

Cancer survivors rank sensorimotor disability among the most distressing, long-term
consequences of chemotherapy. Disorders in gait, balance, and skilled movements are …

Chemotherapy-induced peripheral neuropathy (CIPN) is the most common off-target
adverse effects caused by various chemotherapeutic agents, such as cisplatin, oxaliplatin …

The platinum-based drugs prevail in the therapy of malignant tumors treatment. However,
their clinical outcomes have been heavily restricted by severe systemic toxicities. To ensure …

In pancreatic cancer, significant alterations occur in the local nervous system, including
axonogenesis, neural remodeling, perineural invasion, and perineural neuritis. Pancreatic …

The increased survival of cancer patients has raised growing public health concern on
associated long-term consequences of antineoplastic treatment. Chemotherapy-induced …

Genetic variation is a well-known contributor to the onset and progression of cancer. The
goal of this study is to provide a comprehensive examination of the nucleotide and …