As the major cellular component of the innate immune system in the central nervous system
(CNS) and the first line of defense whenever injury or disease occurs, microglia play a …

Traumatic Brain Injury (TBI) affects a large proportion and extensive array of individuals in
the population. While precise pathological mechanisms are lacking, the growing base of …

Antidepressant treatments enhance plasticity and increase neurogenesis in the adult brain,
but it has been unclear how these effects influence mood. We propose that, like …

Therapeutic effects of antidepressants and atypical antipsychotics may arise partially from
their ability to stimulate neurogenesis. Cannabidiol (CBD), a phytocannabinoid present in …

Controlled cortical impact (CCI) is a commonly used and highly regarded model of brain
trauma that uses a pneumatically or electromagnetically controlled piston to induce …

Background The treatment of traumatic brain injury (TBI) represents an unmet medical need,
as no effective pharmacological treatment currently exists. The development of such a …

Traumatic brain injury (TBI) is induced by mechanical forces which initiate a cascade of
secondary injury processes, including inflammation. Therapies which resolve the …

Traumatic brain injury (TBI) is a pervasive problem in the United States and worldwide, as
the number of diagnosed individuals is increasing yearly and there are no efficacious …

For many decades, research on sphingolipids associated with neurodegenerative disease
focused on alterations in glycosphingolipids, particularly glycosylceramides (cerebrosides) …

New neurons are generated in the hippocampal dentate gyrus from early development
through adulthood. Progenitor cells and immature granule cells in the subgranular zone are …