Myeloid cells are pivotal within the immunosuppressive tumour microenvironment. The
accumulation of tumour-modified myeloid cells derived from monocytes or neutrophils …

Suppression of antitumor immune responses is one of the main mechanisms by which tumor
cells escape from destruction by the immune system. Myeloid-derived suppressor cells …

Purpose Evolving treatments, disease phenotypes, and biology, together with a changing
drug development environment, have created the need to revise castration-resistant prostate …

Introduction Cancer remains a leading cause of death worldwide. While a curative intent is
the aim of any surgical treatment many patients either present with or go onto develop …

Background Neutrophil-to-lymphocyte ratio (NLR) is crucial for the incidence and mortality of
various tumors. However, little is known on NLR and its association with prognosis in …

Prostate cancer remains the most frequently diagnosed cancer in men in North America, and
despite recent advances in treatment patients with metastatic disease continue to have poor …

Background An elevated neutrophil‐to‐lymphocyte ratio (NLR) is associated with poor
survival in patients with cancer, including those who receive immunotherapies. The authors …

It is becoming increasingly clear that inflammation influences prostate cancer (PCa)
development and that immune cells are among the primary drivers of this effect. This …

We investigated the value of the neutrophil–lymphocyte ratio (NLR) in patients with CRPC
treated with chemotherapy in the phase III TROPIC trial. High NLR was associated with …

Prostate cancer is the most commonly diagnosed cancer and the second leading cause of
cancer-related death among men in western countries. Androgen deprivation therapy (ADT) …