Abstract Prolactin (PRL) is a 23-kDa protein hormone that binds to a single-span membrane
receptor, a member of the cytokine receptor superfamily, and exerts its action via several …

Extracellular matrix (ECM) molecules are responsible for structural and biochemical support,
as well as for regulation of molecular signalling and tissue repair in many organ structures …

The generation of insulin-producing pancreatic β cells from stem cells in vitro would provide
an unprecedented cell source for drug discovery and cell transplantation therapy in …

Pancreatic islet encapsulation within biosynthetic materials has had limited clinical success
due to loss of islet function and cell death. As an alternative encapsulation material, a silk …

OBJECTIVE Prolactin is a major stimulus for the β-cell adaptation during gestation and
guards postpartum women against gestational diabetes. Most studies of the role of prolactin …

Context Pre-clinical evidence suggests that prolactin has important metabolic functions in
pregnancy and postpartum, in addition to lactogenic actions. Objective To explore the …

The individual and synergistic effects of extracellular matrix interactions on isolated islet
function in culture were investigated within a three-dimensional poly (ethylene glycol)(PEG) …

Hyperprolactinemia can be caused by several conditions and its effects on the hypothalamic-
pituitary-gonadal axis are understood in more detail. Nevertheless, in recent decades, other …

Aims/hypothesis The proximity of endothelial cells and beta cells in islets by necessity
means that they are exposed to each other's products. Whereas islet endothelial cells …

Islets transplantation, as a treatment of type 1 diabetes, faces challenges, including the loss
of islets in the process of isolation and pre-transplantation due to cellular stresses-induced …