Cytokines and costimulation in acute graft-versus-host disease

GR Hill, M Koyama - Blood, The Journal of the American …, 2020 - ashpublications.org
Allogeneic hematopoietic stem cell transplantation (alloSCT) is an important curative
therapy for high-risk hematological malignancies, but the development of severe and/or …

MAGIC biomarkers predict long-term outcomes for steroid-resistant acute GVHD

H Major-Monfried, AS Renteria… - Blood, The Journal …, 2018 - ashpublications.org
Acute graft-versus-host disease (GVHD) is treated with systemic corticosteroid
immunosuppression. Clinical response after 1 week of therapy often guides further treatment …

Management challenges for chronic dysimmune neuropathies during the COVID‐19 pandemic

YA Rajabally, HS Goedee, S Attarian… - Muscle & …, 2020 - Wiley Online Library
Abstract Since March 2020, the COVID‐19 pandemic has led to the need to re‐think the
delivery of services to patients with chronic dysimmune neuropathies. Telephone/video …

A phase 1 trial of itacitinib, a selective JAK1 inhibitor, in patients with acute graft-versus-host disease

MA Schroeder, HJ Khoury, M Jagasia, H Ali… - Blood …, 2020 - ashpublications.org
Acute graft-versus-host disease (aGVHD) following allogeneic hematopoietic cell
transplantation (HCT) is a primary cause of nonrelapse mortality and a major barrier to …

Unmasking viral sequences by metagenomic next-generation sequencing in adult human blood samples during steroid-refractory/dependent graft-versus-host …

MC Zanella, S Cordey, F Laubscher, M Docquier… - Microbiome, 2021 - Springer
Background Viral infections are common complications following allogeneic hematopoietic
stem cell transplantation (allo-HSCT). Allo-HSCT recipients with steroid …

Glutathione dynamics determine the therapeutic efficacy of mesenchymal stem cells for graft-versus-host disease via CREB1-NRF2 pathway

J Lim, J Heo, H Ju, JW Shin, YH Kim, S Lee, HY Yu… - Science …, 2020 - science.org
Glutathione (GSH), the most abundant nonprotein thiol functioning as an antioxidant, plays
critical roles in maintaining the core functions of mesenchymal stem cells (MSCs), which are …

Low immunosuppressive burden after HLA-matched related or unrelated BMT using posttransplantation cyclophosphamide

CG Kanakry, J Bolaños-Meade… - Blood, The Journal …, 2017 - ashpublications.org
The intensive and prolonged immunosuppressive therapy required to prevent or treat graft-
versus-host disease (GVHD) after allogeneic blood or marrow transplantation (alloBMT) puts …

Effective treatment of low-risk acute GVHD with itacitinib monotherapy

A Etra, A Capellini, A Alousi, MM Al Malki, H Choe… - Blood, 2023 - ashpublications.org
The standard primary treatment for acute graft-versus-host disease (GVHD) requires
prolonged, high-dose systemic corticosteroids (SCSs) that delay reconstitution of the …

Patterns of infection and infection-related mortality in patients with steroid-refractory acute graft versus host disease

I García-Cadenas, I Rivera, R Martino… - Bone Marrow …, 2017 - nature.com
This study aimed to characterize the incidence, etiology and outcome of infectious episodes
in patients with steroid refractory acute GvHD (SR-GvHD). The cohort included 127 adults …

Heterogeneous impact of cytomegalovirus reactivation on nonrelapse mortality in hematopoietic stem cell transplantation

S Kaito, Y Nakajima, K Hara, T Toya, T Nishida… - Blood …, 2020 - ashpublications.org
Cytomegalovirus (CMV) infection is a major complication in allogeneic stem cell
transplantation. The utility of CMV prophylaxis with letermovir has been reported; however …