Molecular testing is becoming an important part of the diagnosis of any patient with cancer.
The challenge to laboratories is to meet this need, using reliable methods and processes to …

The clinical demand for mutation detection within multiple genes from a single tumour
sample requires molecular diagnostic laboratories to develop rapid, high-throughput, highly …

Background: When tumour tissue is unavailable, cell-free DNA (cfDNA) can serve as a
surrogate for genetic analyses. Because mutated alleles in cfDNA are usually below 1 …

Minimally invasive procedures, such as fine needle aspiration and core needle biopsy, are
commonly used for the diagnosis in solid organ malignancies. In the era of targeted therapy …

BACKGROUND The use of cytology specimens for next‐generation sequencing (NGS) is
particularly challenging because of the unconventional substrate of smears and the often …

The advances in understanding the inherited biological mechanisms of non-small cell lung
cancer harbouring epidermal growth factor receptor (EGFR) mutations led to a significant …

BACKGROUND Epidermal growth factor receptor (EGFR) mutations are reliably detected by
referral laboratories, even if most lung cancer cytology specimens sent to such laboratories …

Effusion cytology plays multiple roles in the management of benign and malignant disease,
from primary diagnosis to tissue allocation for ancillary diagnostic studies and biomarker …

Increased understanding of the genetic aetiology of advanced non-small-cell lung cancer
(aNSCLC) has facilitated personalised therapies that target specific molecular aberrations …

Introduction Effusion cytology has a high sensitivity for the diagnosis of malignancy and
provides abundant material for molecular testing. Effusion draining is a minimally invasive …