Metal cations are indispensable components of the cellular machinery and are involved in
numerous essential tasks ranging from nucleic acid and protein structure stabilization to …

Protein design is a valuable tool for understanding the fundamental factors that dictate
protein structure and function. The field of protein design has seen significant progress over …

Zinc is required for the activity of> 300 enzymes, covering all six classes of enzymes. Zinc
binding sites in proteins are often distorted tetrahedral or trigonal bipyramidal geometry …

Carbonic anhydrase (CA; carbonate hydro-lyase, EC 4.2. 1.1) is a zinc-containing enzyme
that catalyzes the reversible hydration of carbon dioxide: CO2+ H2O↔ HCO3−+ H+. The …

Posters and lectures presented at the Seventh International Conference on Bioinorganic
Chemistry (ICBIC) in Lubeck, Germany, last year was divided into 16 sections, including …

Biology capitalizes on the specific chemistries of certain transition metal ions. In fact, life
depends on transition metal ions as essential trace elements. Biological redox processes …

Carbonic anhydrase (CA, EC 4.2. 1.1) is a protein that is especially well-suited to serve as a
model in many types of studies in biophysics, bioanalysis, the physical-organic chemistry of …

Protein‐metal interactions—traditionally regarded for roles in metabolic processes—are now
known to enhance the performance of certain biogenic materials, influencing properties …

The limitations associated with natural enzyme catalysis have triggered the rise of the field of
protein engineering. Traditional rational design was based on the analysis of protein …

The number of zinc enzymes for which detailed structural and mechanistic data, including
high resolution crystal structures, are available is increasing rapidly. The new finding …