Neuroimaging for precision medicine in psychiatry

LM Williams, S Whitfield Gabrieli - Neuropsychopharmacology, 2024 - nature.com
Although the lifetime burden due to mental disorders is increasing, we lack tools for more
precise diagnosing and treating prevalent and disabling disorders such as major depressive …

Ketamine's acute effects on negative brain states are mediated through distinct altered states of consciousness in humans

LM Hack, X Zhang, BD Heifets, T Suppes… - Nature …, 2023 - nature.com
Ketamine commonly and rapidly induces dissociative and other altered states of
consciousness (ASCs) in humans. However, the neural mechanisms that contribute to these …

Integrated behavioral interventions for adults with comorbid obesity and depression: a systematic review

N Lv, EA Kringle, J Ma - Current diabetes reports, 2022 - Springer
Abstract Purpose of Review To synthesize evidence from randomized controlled trials on the
effects of integrated behavioral interventions for comorbid obesity and depression in adults …

Effects of a virtual voice-based coach delivering problem-solving treatment on emotional distress and brain function: a pilot RCT in depression and anxiety

T Kannampallil, OA Ajilore, N Lv, JM Smyth… - Translational …, 2023 - nature.com
Consumer-based voice assistants have the ability to deliver evidence-based treatment, but
their therapeutic potential is largely unknown. In a pilot trial of a virtual voice-based coach …

Adaptive cognitive control circuit changes associated with problem-solving ability and depression symptom outcomes over 24 months

X Zhang, A Pines, P Stetz… - Science Translational …, 2024 - science.org
Mechanistically targeted behavioral interventions are a much-needed strategy for improving
outcomes in depression, especially for vulnerable populations with comorbidities such as …

Astrocyte reactivation in medial prefrontal cortex contributes to obesity-promoted depressive-like behaviors

G Yu, F Cao, T Hou, Y Cheng, B Jia, L Yu… - Journal of …, 2022 - Springer
Background Little is known about how the obesogenic environment influences emotional
states associated with glial responses and neuronal function. Here, we investigated glial …

Validation and adaption of an information-motivation-behavioral skills model of medication adherence in older patients with multimorbidity

C Yang, DTF Lee, SY Chair - Patient Education and Counseling, 2023 - Elsevier
Objective To test and adapt the Information-Motivation-Behavioral Skills (IMB) model in
explaining medication adherence for older patients with multimorbidity. Methods Older …

[HTML][HTML] Towards a consensus roadmap for a new diagnostic framework for mental disorders

MJH Kas, S Hyman, LM Williams… - European …, 2025 - Elsevier
Current nosology claims to separate mental disorders into distinct categories that do not
overlap with each other. This nosological separation is not based on underlying …

Affective neural circuits and inflammatory markers linked to depression and anxiety symptoms in patients with comorbid obesity

H Hallihan, P Tsai, N Lv, L Xiao, BP Bernabé… - Journal of psychiatric …, 2023 - Elsevier
Although we have effective treatments for depression and anxiety, we lack mechanistic
understanding or evidence-based strategies to tailor these treatments in the context of major …

Brain circuit derived biotypes for treatment selection in mood disorders: A critical review and illustration of a functional neuroimaging tool for clinical translation

EJ Song, L Tozzi, LM Williams - Biological Psychiatry, 2024 - Elsevier
Although the lifetime burden due to major depressive disorder is increasing, we lack tools for
selecting the most effective treatments for each patient. A third to one half of patients with …