Recent trends in the design and delivery strategies of ruthenium complexes for breast cancer therapy

U Das, U Basu, P Paira - Dalton Transactions, 2024 - pubs.rsc.org
As the most frequent and deadly type of cancer in women, breast cancer has a high
propensity to spread to the brain, bones, lymph nodes, and lungs. The discovery of cisplatin …

Exploring the Potential of Metal‐Based Candidate Drugs as Modulators of the Cytoskeleton

Y Borutzki, L Skos, C Gerner… - …, 2023 - Wiley Online Library
During recent years, accumulating evidence suggested that metal‐based candidate drugs
are promising modulators of cytoskeletal and cytoskeleton‐associated proteins. This was …

“Half-Sandwich” Ruthenium Complexes with Alizarin as Anticancer Agents: In Vitro and In Vivo Studies

JH de Araujo-Neto, APM Guedes, CM Leite… - Inorganic …, 2023 - ACS Publications
Upon exploration of the chemistry of the combination of ruthenium/arene with anthraquinone
alizarin (L), three new complexes with the general formulas [Ru (L) Cl (η6-p …

New ruthenium complexes containing salicylic acid and derivatives induce triple-negative tumor cell death via the intrinsic apoptotic pathway

AE Graminha, C Popolin, JH de Araujo-Neto… - European Journal of …, 2022 - Elsevier
In this work we present the synthesis and characterization of six new ruthenium compounds
with general formulae [Ru (L)(dppb)(bipy)] PF 6 and [Ru (L)(dppe) 2] PF 6 where L= salicylic …

A novel ruthenium (II) complex with lapachol induces G2/M phase arrest through aurora-B kinase down-regulation and ROS-mediated apoptosis in human prostate …

RA De Grandis, KM Oliveira, APM Guedes… - Frontiers in …, 2021 - frontiersin.org
Lapachol is a well-studied natural product that has been receiving great interest due to its
anticancer properties that target oxidative stress. In the present work, two novel lapachol …

Activation of aryl hydrocarbon receptor signaling by gallic acid suppresses progression of human breast cancer in vitro and in vivo

H Hanieh, HIM Ibrahim, M Mohammed, OI Alwassil… - Phytomedicine, 2022 - Elsevier
Background Despite the significant advances in diagnosis and treatment, breast cancer
remains the most common malignancy and the second cause of death in women …

A ruthenium (II) polypyridyl complex disrupts actin cytoskeleton assembly and blocks cytokinesis

MR Gill, PJ Jarman, V Hearnden… - Angewandte …, 2022 - Wiley Online Library
Abstract The dinuclear RuII complex [(Ru (phen) 2) 2 (tpphz)] 4+(phen= 1, 10‐
phenanthroline, tpphz= tetrapyridophenazine)“RuRuPhen” blocks the transformation of G …

New Palladium(II) Complexes Containing Methyl Gallate and Octyl Gallate: Effect against Mycobacterium tuberculosis and Campylobacter jejuni

RTC Silva, M Guidotti-Takeuchi, JLM Peixoto… - Molecules, 2023 - mdpi.com
This work describes the preparation, characterization and antimicrobial activity of four
palladium (II) complexes, namely,[Pd (meg)(1, 10-phen)] 1,[Pd (meg)(PPh3) 2] 2,[Pd (og)(1 …

Characterization and antibacterial activity of ruthenium-based shikimate cross-linked chitosan composites

R Tao, Y Lu, W Xia, C Zhang, C Wang - International Journal of Biological …, 2022 - Elsevier
The unsustainable antibacterial activity of ruthenium antibacterial agents is an important
factor limiting their applications. This present work attempts to prepare ruthenium (Ru) …

Selective Ru (II)/benzoate complexes against triple-negative breast tumor cells and their interactions with DNA and BSA

T Teixeira, GH Ribeiro, GR Gonçalves, J Honorato… - Inorganica Chimica …, 2024 - Elsevier
New ruthenium (II) complexes bearing benzoate (AB) ligand with the general formula [Ru
(AB)(bipy)(Psingle bondP)] PF6, where 2, 2′-bipyridine (bipy) and different diphosphine …