WNT signaling is an elaborate and complex collection of signal transduction pathways
mediated by multiple signaling molecules. WNT signaling is critically important for …

In 2014, an extensive review discussing the major steps of cardiac development focusing on
growth, formation of primary and chamber myocardium and the development of the cardiac …

Congenital heart disease (CHD) has many forms and a wide range of causes. Clinically, it is
important to understand the causes. This allows estimation of recurrence rate, guides …

Palliative surgery for congenital heart disease has allowed patients with previously lethal
heart malformations to survive and, in most cases, to thrive. However, these procedures …

Cardiovascular disease is the number one killer worldwide, with myocardial infarction (MI)
responsible for approximately 1 in 6 deaths. The lack of endogenous regenerative capacity …

Congenital heart disease (CHD) is the most common birth defect among newborns
worldwide and contributes to significant infant morbidity and mortality. Owing to major …

The heart is the first functioning organ in the developing embryo and a detailed
understanding of the molecular and cellular mechanisms involved in its formation provides …

Wnt/β-catenin signaling pathway plays essential roles in heart development as well as
cardiac tissue homoeostasis in adults. Abnormal regulation of this signaling pathway is …

Activin/SMAD signaling in human embryonic stem cells (hESCs) ensures NANOG
expression and stem cell pluripotency. In the presence of Wnt ligand, the Activin/SMAD …

Secreted frizzled-related proteins (Sfrps) are a family of secreted proteins that bind
extracellularly to Wnt ligands and frizzled receptors. This binding modulates the Wnt …