Drug-induced liver injury (DILI) is one of the leading causes of clinical trial failures and high
drug attrition rates. Currently, the commonly used hepatocyte models include primary human …

The burden of liver diseases is increasing worldwide, accounting for two million deaths
annually. In the past decade, tremendous progress has been made in the basic and …

Nonalcoholic fatty liver disease (NAFLD) is a significant liver disease without approved
therapy, lacking human NAFLD models to aid drug development. Existing models are either …

Cell spheroids are a promising bioprinting building block that can mimic several
physiological conditions in embryonic development. However, it remains challenging to …

Liver tissue engineering approaches aim to support drug testing, assistance devices, or
transplantation. However, their suitability for clinical application remains unsatisfactory …

While various cell responses on material surfaces have been examined, relatively few
reports are focused on significant self-deformation of cell nuclei and corresponding …

Hydrogels are appealing biomaterials for regenerative medicine since biomimetic
modifications of their polymeric network can provide unique physical properties and emulate …

Non-alcoholic fatty liver disease (NAFLD) has become the world's most common chronic
liver disease. However, due to the lack of reliable in vitro NAFLD models, drug development …

Precision remodeling of glycans in their native environments is pivotal for understanding
glycan-mediated biological events and has important biotechnological implications in fields …

Background: In vitro three-dimensional (3D) hepatic spheroid culture has shown great
promise in toxicity testing because it better mimics the cell–cell and cell–matrix interactions …