HFIP in organic synthesis

HF Motiwala, AM Armaly, JG Cacioppo… - Chemical …, 2022 - ACS Publications
1, 1, 1, 3, 3, 3-Hexafluoroisopropanol (HFIP) is a polar, strongly hydrogen bond-donating
solvent that has found numerous uses in organic synthesis due to its ability to stabilize ionic …

Recent Advances in Alkenyl sp2 C–H and C–F Bond Functionalizations: Scope, Mechanism, and Applications

MZ Lu, J Goh, M Maraswami, Z Jia, JS Tian… - Chemical …, 2022 - ACS Publications
Alkenes and their derivatives are featured widely in a variety of natural products,
pharmaceuticals, and advanced materials. Significant efforts have been made toward the …

Transition‐Metal‐Mediated and‐Catalyzed C− F Bond Activation by Fluorine Elimination

T Fujita, K Fuchibe, J Ichikawa - … Chemie International Edition, 2019 - Wiley Online Library
The activation of carbon–fluorine (C− F) bonds is an important topic in synthetic organic
chemistry. Metal‐mediated and‐catalyzed elimination of β‐or α‐fluorine proceeds under …

Recent advances in the synthesis and CF functionalization of gem-difluoroalkenes

X Zhang, S Cao - Tetrahedron Letters, 2017 - Elsevier
The gem-difluoroalkenes and related compounds have gained much attention from the
organic synthetic community due to their widespread applications as versatile fluorinated …

Review of recent advances in CF bond activation of aliphatic fluorides

Q Shen, YG Huang, C Liu, JC Xiao, QY Chen… - Journal of Fluorine …, 2015 - Elsevier
Csingle bondF bond activation of aliphatic fluorides provides new methodologies for
synthesis of new fluorinated building blocks as well as versatile non-fluorinated products …

[HTML][HTML] Rhodium-catalysed C (sp2)–C (sp2) bond formation via C–H/C–F activation

P Tian, C Feng, TP Loh - Nature Communications, 2015 - nature.com
Fluoroalkenes represent a class of privileged structural motifs, which found widespread use
in medicinal chemistry. However, the synthetic access to fluoroalkenes was much …

Recent Advances in Transition Metal‐Catalyzed Functionalization of gem‐Difluoroalkenes

S Koley, RA Altman - Israel journal of chemistry, 2020 - Wiley Online Library
Abstract gem‐Difluorinated alkenes are readily accessible building blocks that can undergo
functionalization to provide a broad spectrum of fluorinated and non‐fluorinated products …

Rh (III)-catalyzed cascade reactions of sulfoxonium ylides with α-diazocarbonyl compounds: an access to highly functionalized naphthalenones

X Chen, M Wang, X Zhang, X Fan - Organic letters, 2019 - ACS Publications
An unprecedented cascade reaction of benzoyl sulfoxonium ylides with α-diazocarbonyl
compounds leading to the formation of highly functionalized naphthalenones containing a β …

Diastereoselective Synthesis of Monofluorocyclohexenes through Photocatalyzed Cascade Cyclization of gem‐Difluoroalkenes and α,β‐Unsaturated Carbonyl …

Z Li, Y Zhang, Y Zhang, X He, X Shen - Angewandte Chemie, 2023 - Wiley Online Library
Monofluoroalkenes are nonhydrolyzable mimetics of amides. Previous work focused on the
synthesis of non‐cyclic monofluoroalkenes. However, diastereoselective synthesis of …

Difluoromethyl 2-Pyridyl Sulfone: A New gem-Difluoroolefination Reagent for Aldehydes and Ketones

Y Zhao, W Huang, L Zhu, J Hu - Organic Letters, 2010 - ACS Publications
Difluoromethyl 2-pyridyl sulfone, a previously unknown compound, was found to act as a
novel and efficient gem-difluoroolefination reagent for both aldehydes and ketones. It was …