Computational systems biology in disease modeling and control, review and perspectives

R Yue, A Dutta - npj Systems Biology and Applications, 2022 - nature.com
Omics-based approaches have become increasingly influential in identifying disease
mechanisms and drug responses. Considering that diseases and drug responses are co …

Bioresponsive hydrogels

AN Wilson, A Guiseppi‐Elie - Advanced healthcare materials, 2013 - Wiley Online Library
Bioresponsive hydrogels are emerging with technological significance in targeted drug
delivery, biosensors, and regenerative medicine. Their ability to respond to specific …

Stabilization of positive switched linear systems and its application in consensus of multiagent systems

Y Sun, Y Tian, XJ Xie - IEEE Transactions on Automatic Control, 2017 - ieeexplore.ieee.org
In this note, we study the stabilization problem of positive switched linear system (PSLS) with
disturbance. By introducing a class of weak common linear copositive Lyapunov functions …

Model predictive control using MISO approach for drug co-administration in anesthesia

A Pawłowski, M Schiavo, N Latronico… - Journal of Process …, 2022 - Elsevier
In this paper, a model predictive control system for the depth of hypnosis is proposed and
analyzed. This approach considers simultaneous co-administration of the hypnotic and …

Stabilization of discrete-time switched positive linear systems via weak switched linear copositive Lyapunov function

Y Ju, Y Sun - Automatica, 2020 - Elsevier
By introducing a class of weak switched linear copositive Lyapunov functions, this paper
designs new time-dependent switching signals guaranteeing asymptotic stability of discrete …

Nonlinear identification of a minimal neuromuscular blockade model in anesthesia

MM da Silva, T Wigren… - IEEE Transactions on …, 2011 - ieeexplore.ieee.org
This brief presents new modeling and identification strategies to address many difficulties in
the identification of anesthesia dynamics. The most commonly used models for the effect of …

Computing the viability kernel using maximal reachable sets

S Kaynama, J Maidens, M Oishi, IM Mitchell… - Proceedings of the 15th …, 2012 - dl.acm.org
We present a connection between the viability kernel and maximal reachable sets. Current
numerical schemes that compute the viability kernel suffer from a complexity that is …

Linear MPC for anesthesia process with external predictor

A Pawłowski, M Schiavo, N Latronico… - Computers & Chemical …, 2022 - Elsevier
In this paper we present a new model predictive control system for the depth of hypnosis in
general anesthesia. The depth of hypnosis is measured by the Bispectral Index Scale signal …

A computationally efficient Hill curve adaptation strategy during continuous monitoring of dose–effect relation in anaesthesia

CM Ionescu - Nonlinear Dynamics, 2018 - Springer
This paper discusses a possibility to simplify the number of parameters in the Hill curve by
exploiting special mathematical functions. This simplification is relevant when adaptation is …

Exponential stability of switched linear impulsive time-varying system and its application

Y Ju, F Meng, Y Sun - Journal of the Franklin Institute, 2022 - Elsevier
This paper aims at the problem of exponential stability for switched linear impulsive time-
varying system. By constructing two different switched discretized Lyapunov functions, some …