Human health is under constant threat of a wide variety of dangers, both self and nonself.
The immune system is occupied with protecting the host against such dangers in order to …

Within the past 10 years the field of signaling via extracellular nucleotides has witnessed a
breath-taking expansion. Molecular cloning of receptors and physiological and …

Nucleotides are emerging as an ubiquitous family of extracellular signaling molecules. It has
been known for many years that adenosine diphosphate is a potent platelet aggregating …

The ecto-nucleotide pyrophosphatase/phosphodiesterase (E-NPP) multigene family
contains five members. NPP1-3 are type II transmembrane metalloenzymes characterized …

Alzheimer's disease (AD) is the most common form of dementia and associated with the
progressive accumulation of amyloid β-peptides (Aβ) in form of extracellular amyloid …

Abstract Histidine-rich glycoprotein (HRG), also known as histidine-proline-rich glyco-
protein, is an abundant and well-characterized protein of vertebrate plasma. HRG has a …

Physiological evidence supporting the role of the adenine nucleotide, ATP 1 (Figure 1), as a
neurotransmitter was first summarized in detail in 1972, 1 representing the basis of …

Alzheimer's disease (AD) is the most common form of dementia and associated with
progressive deposition of amyloid β‐peptides (Aβ) in the brain. Aβ derives by sequential …

In addition to its key role in cellular metabolism where it acts as a ubiquitous enzyme
cofactor and as the key source of the cellular energy unique to phosphate bond formation …

Leukocyte trafficking between the blood and the tissues is pivotal for normal immune
responses. Cell-adhesion molecules (such as selectins and leukocyte integrins) and …