No cell lives in a vacuum, and the molecular interactions between cells define most
phenotypes. Transcriptomics provides rich information to infer cell–cell interactions and …

Natural products have long served as critical raw materials in chemical and pharmaceutical
manufacturing, primarily which can provide superior scaffolds or intermediates for drug …

Transcription induces a wave of DNA supercoiling, altering the binding affinity of RNA
polymerases and reshaping the biochemical landscape of gene regulation. As supercoiling …

Context-dependency of mammalian transcriptional elements has hindered the quantitative
investigation of multigene expression stoichiometry and its biological functions. Here, we …

Massively parallel genetic screens have been used to map sequence-to-function
relationships for a variety of genetic elements. However, because these approaches only …

Biohybrid devices based on engineered cells interfaced with bioelectronics represent a
promising union where the strengths of each field can be synergistically combined, resulting …

Augmenting cells with novel, genetically encoded functions will support therapies that
expand beyond natural capacity for immune surveillance and tissue regeneration. However …

DNA molecules can be adopted to design biomolecular control circuits that can effectively
control biochemical reaction processes. However, the leak reaction in actual biochemical …

Synthetic biology has many valuable applications, but it also gives rise to certain risks. In this
paper I discuss the risk of bioterrorism, which often attracts attention in both the mass media …

Synthetic biology (SynBio) is an emerging field of study with great potential in designing,
engineering, and constructing new microbial synthetic cells that do not pre-exist in nature or …