At least 38 viral species are transmitted by ticks. Virus–tick–vertebrate host relationships are
highly specific and less than 10% of all tick species (Argasidae and Ixodidae) are known to …

Efficient in vitro and in vivo systems are now in place to study the role of viral proteins in
replication and/or transcription, the regulation of these processes, polyadenylation of viral …

Mx proteins belong to the dynamin superfamily of high molecular weight GTPases and
interfere with multiplication of a wide variety of viruses. Earlier studies show that nuclear …

MxA is a large, interferon-induced GTPase with antiviral activity against RNA viruses. It forms
large oligomers, but whether oligomerization and GTPase activity are important for antiviral …

The recovery of recombinant influenza A virus entirely from cDNA was recently described (9,
19). We adapted the technique for engineering influenza B virus and generated a mutant …

Reverse genetics is defined as the generation of virus entirely from cloned eDNA. For
negative-sense RNA viruses, whose genomes are complementary to mRNA in their …

Human MxA protein accumulates in the cytoplasm of interferon-treated cells and inhibits the
multiplication of several RNA viruses, including Thogoto virus (THOV), a tick-borne …

Abstract Heartland (HRTV) and Bourbon (BRBV) viruses are newly identified tick-borne
viruses, isolated from serious clinical cases in 2009 and 2014, respectively. Both viruses …

The recent discovery of Bourbon virus (BRBV) put a new focus on the genus of
thogotoviruses as zoonotic, tick-transmitted pathogens within the orthomyxovirus family …

ABSTRACT Myxovirus resistance 1 (Mx1) is an interferon-induced gene that encodes a
GTPase that plays an important role in the defense of mammalian cells against influenza A …